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• W2551599160 abstract "A ligand-observed 1H NMR relaxation experiment is introduced for measuring the binding kinetics of low-molecular-weight compounds to their biomolecular targets. We show that this approach, which does not require any isotope labeling, is applicable to ligand–target systems involving proteins and nucleic acids of variable molecular size. The experiment is particularly useful for the systematic investigation of low affinity molecules with residence times in the micro- to millisecond time regime." @default.
• W2551599160 created "2016-11-30" @default.
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• W2551599160 date "2016-11-29" @default.
• W2551599160 modified "2023-10-18" @default.
• W2551599160 title "Measurement of Ligand–Target Residence Times by ¹H Relaxation Dispersion NMR Spectroscopy" @default.
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• W2551599160 doi "https://doi.org/10.1021/acs.jmedchem.6b01110" @default.
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