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• W2551640496 abstract "Background Treatment-emergent mania/hypomania (TEM) is a possible adverse effect of pharmacological and non-pharmacological antidepressant treatments. Objective We performed a systematic review and meta-analysis to evaluate the risk of TEM in depressed patients during randomized, sham-controlled trials (RCTs). Data sources Medline database, from the first date available to August 12, 2016. Results From 283 references, 10 RCTs were identified. Only 3 of them described TEM. In active and sham groups, respectively, only 8 of 226 (3.5%) and 1 of 190 (0.5%) participants presented TEM. This difference was not statistically significant (OR = 1.79, 95% CI = 0.6 to 5.32). There were also five additional reports of TEM in participants not on RCTs. No risk factors for TEM were identified. Limitations Low number of studies and TEM reports. Conclusion Despite previous reports, active vs. sham tDCS was not associated with a significantly greater number of TEM episodes." @default.
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• W2551640496 date "2017-03-01" @default.
• W2551640496 modified "2023-10-10" @default.
• W2551640496 title "Treatment-emergent mania/hypomania during antidepressant treatment with transcranial direct current stimulation (tDCS): A systematic review and meta-analysis" @default.
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• W2551640496 doi "https://doi.org/10.1016/j.brs.2016.11.005" @default.
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