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• W2551813366 abstract "The objective of the present study was to microencapsulate the anti-inflammatory drug (Aceclofenac) to provide controlled release and to minimize or eliminate local side effects by avoiding drug release in the upper gastrointestinal tract. The drug was targeted to the colon and its aligned areas for local effects. Aceclofenac was microencapsulated with guar gum or modified guar gum (carboxymethyl guar gum) and pectin using an ionotropic-gelation technique. Aceclofenac microspheres were subjected to micromeritic properties, drug loading, invitro drug release as well as SEM, DSC, FT-IR spectroscopy and a swelling study (swelling index and swelling kinetics), among others. The prepared microspheres were light yellowish in colour, free-flowing, and almost spherical in shape. The drug-loaded microspheres showed 57.28 to 81.73% drug entrapment efficiency and particle size ranged from 0.80 to 1.10 mm. The DSC study showed the possibility of a weak non-covalent interaction between drug and polymer which may be due to H-bonding or an ionic interaction. The swelling study showed a swelling index of 0.7 at pH 1.2 and 1.2 at pH 6.8; at both pHs, the swelling followed a zero-order kinetics. The FT-IR spectra showed a peak at 1742.65 cm -1 , which confirms the carboxymethylation of guar gum. FT-IR spectra of drug-loaded beads indicate that the drug was properly loaded. In-vitro drug release studies were carried out up to 8 h in 0.02M phosphate buffer (pH 6.8) and up to 2 h in 0.1 N HCl (pH 1.2). All the formulations followed a Higuchi-Matrix model of release kinetics." @default.
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• W2551813366 date "2011-01-01" @default.
• W2551813366 modified "2023-09-22" @default.
• W2551813366 title "Development and Evaluation of Colonic Drug Delivery of Aceclofenac using Pectin and Guar Gum" @default.
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