Matches in SemOpenAlex for { <https://semopenalex.org/work/W2551829503> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2551829503 abstract "Abstract Broad spectrum antibiotics are sometimes used prophylactically during the neutropenic phase of stem cell transplantation, but this practice is controversial. Possible benefits include the prevention of fever and infectious episodes. Possible disadvantages include increased usage of antibiotics with associated increases in cost, toxicities and development of antibiotic resistance. OBJECTIVE: To compare prophylactic (PRO) administration of ceftazidime at the beginning of neutropenia (ANC <500) vs. empirical (EMP) initiation of ceftazidime for neutropenic fever in RIST patients during the pre-engraftment period. METHODS: Retrospective analysis of all patients who received a RIST for hematologic malignancies in two different bone marrow transplant units at the NIH Clinical Center between 2000 and 2003. The PRO group was composed of 41 patients who received prophylactic ceftazidime 2 g iv q 8h when ANC <500. The EMP group was composed of 40 patients who received ceftazidime during neutropenia only if fever developed. Both groups were comparable in terms of baseline disease, age, sex, conditioning regimen (FLU/CY) and gut decontamination. Mean duration of neutropenia was 10.8 days in the PRO group and 13.7 days in the EMP group (p < 0.05), due to differences in GVHD prophylaxis and GCSF usage. RESULTS: The PRO group presented less episodes of neutropenic fever (16/41, 39% vs. 27/40, 67.5%, p < 0.05), less microbiologically documented infections (4/41, 10% vs 17/40, 43% p < 0.05) and less episodes of bacteremia (1 vs. 7). By Kaplan-Meier analysis the median time to developing fever was significantly longer in the PRO group (9.6 vs 6.8 days p = 0.03). The PRO group received, on average, 5.5 less days of broad-spectrum antibiotics (11.8 vs 17.3). The average number of days on ceftazidime was 10 in the PRO group and 7 in the EMP group. There were no significant toxicities associated with antibiotic use. The susceptibility to ceftazidime on the bacterial isolates from both transplant units did not change significantly between 1999 and 2003, despite the different patterns of antibiotic use. CONCLUSION: Prophylaxis with ceftazidime may prevent neutropenic fever and microbiologically documented infections during the pre-engraftment phase of RIST, and may result in decreased utilization of broad-spectrum antibiotics." @default.
- W2551829503 created "2016-11-30" @default.
- W2551829503 creator A5011431831 @default.
- W2551829503 creator A5023659191 @default.
- W2551829503 creator A5028419340 @default.
- W2551829503 creator A5042150016 @default.
- W2551829503 creator A5044239219 @default.
- W2551829503 creator A5074220802 @default.
- W2551829503 creator A5076074380 @default.
- W2551829503 creator A5083730467 @default.
- W2551829503 creator A5087281194 @default.
- W2551829503 creator A5089893290 @default.
- W2551829503 date "2004-11-16" @default.
- W2551829503 modified "2023-10-14" @default.
- W2551829503 title "Comparison of Empiric Versus Prophylactic Administration of Ceftazidime during Neutropenia Associated with Reduced-Intensity Allogeneic Stem Cell Transplantation (RIST)." @default.
- W2551829503 doi "https://doi.org/10.1182/blood.v104.11.5100.5100" @default.
- W2551829503 hasPublicationYear "2004" @default.
- W2551829503 type Work @default.
- W2551829503 sameAs 2551829503 @default.
- W2551829503 citedByCount "0" @default.
- W2551829503 crossrefType "journal-article" @default.
- W2551829503 hasAuthorship W2551829503A5011431831 @default.
- W2551829503 hasAuthorship W2551829503A5023659191 @default.
- W2551829503 hasAuthorship W2551829503A5028419340 @default.
- W2551829503 hasAuthorship W2551829503A5042150016 @default.
- W2551829503 hasAuthorship W2551829503A5044239219 @default.
- W2551829503 hasAuthorship W2551829503A5074220802 @default.
- W2551829503 hasAuthorship W2551829503A5076074380 @default.
- W2551829503 hasAuthorship W2551829503A5083730467 @default.
- W2551829503 hasAuthorship W2551829503A5087281194 @default.
- W2551829503 hasAuthorship W2551829503A5089893290 @default.
- W2551829503 hasConcept C126322002 @default.
- W2551829503 hasConcept C141071460 @default.
- W2551829503 hasConcept C2776694085 @default.
- W2551829503 hasConcept C2776968632 @default.
- W2551829503 hasConcept C2777063308 @default.
- W2551829503 hasConcept C2777637488 @default.
- W2551829503 hasConcept C2778850193 @default.
- W2551829503 hasConcept C2779181126 @default.
- W2551829503 hasConcept C2911091166 @default.
- W2551829503 hasConcept C501593827 @default.
- W2551829503 hasConcept C523546767 @default.
- W2551829503 hasConcept C54355233 @default.
- W2551829503 hasConcept C71924100 @default.
- W2551829503 hasConcept C86803240 @default.
- W2551829503 hasConcept C89423630 @default.
- W2551829503 hasConcept C90924648 @default.
- W2551829503 hasConceptScore W2551829503C126322002 @default.
- W2551829503 hasConceptScore W2551829503C141071460 @default.
- W2551829503 hasConceptScore W2551829503C2776694085 @default.
- W2551829503 hasConceptScore W2551829503C2776968632 @default.
- W2551829503 hasConceptScore W2551829503C2777063308 @default.
- W2551829503 hasConceptScore W2551829503C2777637488 @default.
- W2551829503 hasConceptScore W2551829503C2778850193 @default.
- W2551829503 hasConceptScore W2551829503C2779181126 @default.
- W2551829503 hasConceptScore W2551829503C2911091166 @default.
- W2551829503 hasConceptScore W2551829503C501593827 @default.
- W2551829503 hasConceptScore W2551829503C523546767 @default.
- W2551829503 hasConceptScore W2551829503C54355233 @default.
- W2551829503 hasConceptScore W2551829503C71924100 @default.
- W2551829503 hasConceptScore W2551829503C86803240 @default.
- W2551829503 hasConceptScore W2551829503C89423630 @default.
- W2551829503 hasConceptScore W2551829503C90924648 @default.
- W2551829503 hasLocation W25518295031 @default.
- W2551829503 hasOpenAccess W2551829503 @default.
- W2551829503 hasPrimaryLocation W25518295031 @default.
- W2551829503 hasRelatedWork W2002245589 @default.
- W2551829503 hasRelatedWork W2012778188 @default.
- W2551829503 hasRelatedWork W2046333296 @default.
- W2551829503 hasRelatedWork W2078472716 @default.
- W2551829503 hasRelatedWork W2089410660 @default.
- W2551829503 hasRelatedWork W2113085733 @default.
- W2551829503 hasRelatedWork W2162075629 @default.
- W2551829503 hasRelatedWork W2338573145 @default.
- W2551829503 hasRelatedWork W253883249 @default.
- W2551829503 hasRelatedWork W2883054929 @default.
- W2551829503 isParatext "false" @default.
- W2551829503 isRetracted "false" @default.
- W2551829503 magId "2551829503" @default.
- W2551829503 workType "article" @default.