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- W2551901919 abstract "Development![Figure][1] Protonephridia of the planarian excretory systemPHOTO: H. T.-K. VU ET AL., ELIFE (9 JUNE 2015) © 2015 ELIFE SCIENCES PUBLICATIONS LTD.Individuals with polycystic kidney disease (PKD) develop fluid-filled cysts in their nephrons that interfere with kidney function. Looking for a suitable invertebrate model of PKD, Vu et al. discovered that the excretory system of planarian flatworms is a good model for normal and diseased human kidneys. The planarian protonephridia shares structural similarities with the subsegments of the vertebrate nephron, and both organisms use cilia-driven ultrafiltration and filtrate modification. Moreover, mutating planarian orthologs of human genes resulted in phenotypes and pathologies similar to those seen in human PKD.eLife 10.7554/eLife.07405 (2015). [1]: pending:yes" @default.
- W2551901919 created "2016-11-30" @default.
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- W2551901919 date "2015-07-09" @default.
- W2551901919 modified "2023-09-26" @default.
- W2551901919 title "Planaria have model kidneys" @default.
- W2551901919 doi "https://doi.org/10.1126/science.349.6244.151-a" @default.
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