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- W2551910432 abstract "Selective decontamination of the digestive tract (SDD) reduces infections and mortality in intensive care patients.[1,2] By the local application of tobramycin, polymyxin and amphotericin in the oropharynx and gastrointestinal tract, SDD eradicates Staphylococcus aureus, Gram-negative rods and yeasts, which are potentially pathogenic. If the gut barrier is intact, the antibiotics are not absorbed and remain in the digestive tract. However, during shock and sepsis, the gut barrier may fail, allowing leakage of antibiotics from the gut into the circulation. This phenomenon is especially described for tobramycin, the smallest constituent of SDD.[3-5] If kidney function is diminished as well, subsequent removal of tobramycin is delayed and the drug may become toxic for the kidneys.[6] Thus shock, sepsis and acute kidney injury are risk factors for the leakage of tobramycin from the gut.[5]" @default.
- W2551910432 created "2016-11-30" @default.
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- W2551910432 date "2015-01-01" @default.
- W2551910432 modified "2023-09-24" @default.
- W2551910432 title "Tobramycin leakage from the gut: What about the other components of SDD?" @default.
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