FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2551939312> ?p ?o ?g. }

• W2551939312 endingPage "e3888" @default.
• W2551939312 startingPage "e3888" @default.
• W2551939312 abstract "Pinostrobin (PI, 5-hydroxy-7-methoxyflavanone) is a natural flavonoid known for its rich pharmacological activities. The objective of this study was to identify the human liver cytochrome P450 (CYP450) isoenzymes involved in the metabolism of PI. A single hydoxylated metabolite was obtained from PI after an incubation with pooled human liver microsomes (HLMs). The relative contributions of different CYP450s were evaluated using CYP450-selective inhibitors in HLMs and recombinant human CYP450 enzymes, and the results revealed the major involvement of CYP1A2, CYP2C9 and CYP2E1 in PI metabolism. We also evaluated the ability of PI to inhibit and induce human cytochrome P450 enzymes in vitro. High-performance liquid chromatography and liquid chromatography–tandem mass spectrometry analytical techniques were used to estimate the enzymatic activities of seven drug-metabolizing CYP450 isozymes in vitro. In HLMs, PI did not inhibit CYP 1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 or CYP3A4 (IC50 > 100 μm). In the induction studies, PI had minimal effects on CYP1A2, CYP2B6and CYP3A4 activity. Based on these results, PI would not be expected to cause clinically significant CYP450 inhibition or induction." @default.
• W2551939312 created "2016-11-30" @default.
• W2551939312 creator A5008777575 @default.
• W2551939312 creator A5016042893 @default.
• W2551939312 creator A5047835477 @default.
• W2551939312 creator A5051156967 @default.
• W2551939312 creator A5052981792 @default.
• W2551939312 creator A5056449420 @default.
• W2551939312 date "2017-01-22" @default.
• W2551939312 modified "2023-10-03" @default.
• W2551939312 title "Cytochrome P450 reaction phenotyping and inhibition and induction studies of pinostrobin in human liver microsomes and hepatocytes" @default.
• W2551939312 cites W1815513732 @default.
• W2551939312 cites W1965134354 @default.
• W2551939312 cites W1987768752 @default.
• W2551939312 cites W1991359947 @default.
• W2551939312 cites W2002312856 @default.
• W2551939312 cites W2002884027 @default.
• W2551939312 cites W2004108847 @default.
• W2551939312 cites W2004468610 @default.
• W2551939312 cites W2006073786 @default.
• W2551939312 cites W2008727945 @default.
• W2551939312 cites W2018041278 @default.
• W2551939312 cites W2024110631 @default.
• W2551939312 cites W2047402977 @default.
• W2551939312 cites W2051520396 @default.
• W2551939312 cites W2062753542 @default.
• W2551939312 cites W2074451871 @default.
• W2551939312 cites W2079110718 @default.
• W2551939312 cites W2085489841 @default.
• W2551939312 cites W2100450267 @default.
• W2551939312 cites W2102697458 @default.
• W2551939312 cites W2104478003 @default.
• W2551939312 cites W2119122217 @default.
• W2551939312 cites W2136176655 @default.
• W2551939312 cites W2142916564 @default.
• W2551939312 cites W2147341925 @default.
• W2551939312 cites W2154382954 @default.
• W2551939312 cites W2157282781 @default.
• W2551939312 cites W2173978055 @default.
• W2551939312 cites W2218060788 @default.
• W2551939312 cites W2291760605 @default.
• W2551939312 cites W2319740464 @default.
• W2551939312 cites W2325009591 @default.
• W2551939312 cites W2462159865 @default.
• W2551939312 cites W2462221119 @default.
• W2551939312 cites W2474613199 @default.
• W2551939312 doi "https://doi.org/10.1002/bmc.3888" @default.
• W2551939312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28111763" @default.
• W2551939312 hasPublicationYear "2017" @default.
• W2551939312 type Work @default.
• W2551939312 sameAs 2551939312 @default.
• W2551939312 citedByCount "3" @default.
• W2551939312 countsByYear W25519393122017 @default.
• W2551939312 countsByYear W25519393122018 @default.
• W2551939312 countsByYear W25519393122023 @default.
• W2551939312 crossrefType "journal-article" @default.
• W2551939312 hasAuthorship W2551939312A5008777575 @default.
• W2551939312 hasAuthorship W2551939312A5016042893 @default.
• W2551939312 hasAuthorship W2551939312A5047835477 @default.
• W2551939312 hasAuthorship W2551939312A5051156967 @default.
• W2551939312 hasAuthorship W2551939312A5052981792 @default.
• W2551939312 hasAuthorship W2551939312A5056449420 @default.
• W2551939312 hasConcept C109650736 @default.
• W2551939312 hasConcept C115368759 @default.
• W2551939312 hasConcept C119795356 @default.
• W2551939312 hasConcept C140027455 @default.
• W2551939312 hasConcept C181199279 @default.
• W2551939312 hasConcept C185592680 @default.
• W2551939312 hasConcept C2777477808 @default.
• W2551939312 hasConcept C33664856 @default.
• W2551939312 hasConcept C3946865 @default.
• W2551939312 hasConcept C43617362 @default.
• W2551939312 hasConcept C50605568 @default.
• W2551939312 hasConcept C526171541 @default.
• W2551939312 hasConcept C55493867 @default.
• W2551939312 hasConcept C86745063 @default.
• W2551939312 hasConcept C86803240 @default.
• W2551939312 hasConcept C87644729 @default.
• W2551939312 hasConcept C98274493 @default.
• W2551939312 hasConceptScore W2551939312C109650736 @default.
• W2551939312 hasConceptScore W2551939312C115368759 @default.
• W2551939312 hasConceptScore W2551939312C119795356 @default.
• W2551939312 hasConceptScore W2551939312C140027455 @default.
• W2551939312 hasConceptScore W2551939312C181199279 @default.
• W2551939312 hasConceptScore W2551939312C185592680 @default.
• W2551939312 hasConceptScore W2551939312C2777477808 @default.
• W2551939312 hasConceptScore W2551939312C33664856 @default.
• W2551939312 hasConceptScore W2551939312C3946865 @default.
• W2551939312 hasConceptScore W2551939312C43617362 @default.
• W2551939312 hasConceptScore W2551939312C50605568 @default.
• W2551939312 hasConceptScore W2551939312C526171541 @default.
• W2551939312 hasConceptScore W2551939312C55493867 @default.
• W2551939312 hasConceptScore W2551939312C86745063 @default.
• W2551939312 hasConceptScore W2551939312C86803240 @default.
• W2551939312 hasConceptScore W2551939312C87644729 @default.
• W2551939312 hasConceptScore W2551939312C98274493 @default.
• W2551939312 hasFunder F4320321543 @default.
• W2551939312 hasIssue "6" @default.

• next