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- W2551948902 abstract "Radiation exposure of living organisms is known to produce many harmful effects in biological systems due to generation of free radicals. Many antioxidants have been investigated as hepato-protectors against ionizing radiation induced injury since they reduce the oxidative effect of the reactive oxygen species on normal cells. Spirulina platensis is a potent scavenger of a variety of free radicals. The aim of this study was to investigate the radio-protective effect of Spirulina platensis algae against oxidative stress and tissue injury caused by gamma radiation. Rats irradiated at 5 Gy delivered as single dose produced a significant decrease in albumin, total protein and globulin levels as compared to normal control rats. However, γ-irradiated rats pre-treated with Spirulina increased significantly albumin, total protein and globulin levels as compared to gamma irradiated rats (5 Gy). Rats irradiated at 5 Gy produced a significant increase in the activity of the liver enzymes, ALT, AST, ALP and GGT. Meanwhile, gamma irradiated rats pre- treated with Spirulina platensis decreased significantly ALT, AST, ALP and GGT as compared to gamma irradiated rats. Gamma irradiated rats increased significantly cholesterol, triglyceride, HDL and LDL as compared to normal control rats. Also, gamma irradiated rats pre-treated with Spirulina platensis decreased significantly cholesterol, triglyceride, HDL and LDL as compared to gamma irradiated rats. Kidney function tests, creatinine, urea and potassium increased significantly in γ-irradiated rats as compared to normal control rats. Meanwhile, in Spirulina platensis pre-treated animals before irradiation decreased significantly creatinine, urea and potassium as compared to gamma irradiated rats. . Gamma irradiated rats (5 Gy) decreased significantly the antioxidant enzyme activity of GSH, GPX, CAT, and SOD as compared to normal control rats. Also, γ-irradiated rats pre-treated with Spirulina increased significantly GSH, GPX, CAT, and SOD as compared to γ-irradiated rats. It was concluded that administration of Spirulina platensis algae possess a radio protective capacity against ionizing-radiation induced oxidative stress and organ injury. Thus, supplementation with Spirulina platensis may have a benefit for safe application of radiation technology in medicine and industry." @default.
- W2551948902 created "2016-11-30" @default.
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- W2551948902 date "2015-01-01" @default.
- W2551948902 modified "2023-09-23" @default.
- W2551948902 title "Amelioration of Oxidative Stress Induced by Gamma Irradiation in Rats Using Spirulina platensis" @default.
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