Matches in SemOpenAlex for { <https://semopenalex.org/work/W2551965620> ?p ?o ?g. }
- W2551965620 abstract "Nanog is a master pluripotency factor of embryonic stem cells (ESCs). Stable expression of Nanog is essential to maintain the stemness of ESCs. However, Nanog is a short-lived protein and quickly degraded by the ubiquitin-dependent proteasome system. Here we report that the deubiquitinase USP21 interacts with, deubiquitinates and stabilizes Nanog, and therefore maintains the protein level of Nanog in mouse ESCs (mESCs). Loss of USP21 results in Nanog degradation, mESCs differentiation and reduces somatic cell reprogramming efficiency. USP21 is a transcriptional target of the LIF/STAT3 pathway and is downregulated upon differentiation. Moreover, differentiation cues promote ERK-mediated phosphorylation and dissociation of USP21 from Nanog, thus leading to Nanog degradation. In addition, USP21 is recruited to gene promoters by Nanog to deubiquitinate histone H2A at K119 and thus facilitates Nanog-mediated gene expression. Together, our findings provide a regulatory mechanism by which extrinsic signals regulate mESC fate via deubiquitinating Nanog." @default.
- W2551965620 created "2016-11-30" @default.
- W2551965620 creator A5005381760 @default.
- W2551965620 creator A5008044292 @default.
- W2551965620 creator A5027272944 @default.
- W2551965620 creator A5029547796 @default.
- W2551965620 creator A5029695887 @default.
- W2551965620 creator A5029718321 @default.
- W2551965620 creator A5036670052 @default.
- W2551965620 creator A5037461695 @default.
- W2551965620 creator A5047034683 @default.
- W2551965620 creator A5053044736 @default.
- W2551965620 creator A5060165452 @default.
- W2551965620 creator A5060241560 @default.
- W2551965620 creator A5079819407 @default.
- W2551965620 creator A5089020165 @default.
- W2551965620 date "2016-11-25" @default.
- W2551965620 modified "2023-10-11" @default.
- W2551965620 title "The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog" @default.
- W2551965620 cites W1419940491 @default.
- W2551965620 cites W1608762409 @default.
- W2551965620 cites W1653306654 @default.
- W2551965620 cites W1963962669 @default.
- W2551965620 cites W1965428318 @default.
- W2551965620 cites W1966758700 @default.
- W2551965620 cites W1967415928 @default.
- W2551965620 cites W1967592534 @default.
- W2551965620 cites W1969932442 @default.
- W2551965620 cites W1975200987 @default.
- W2551965620 cites W1981986780 @default.
- W2551965620 cites W1982819726 @default.
- W2551965620 cites W1985299376 @default.
- W2551965620 cites W1990211949 @default.
- W2551965620 cites W1997506291 @default.
- W2551965620 cites W1997739317 @default.
- W2551965620 cites W2007256989 @default.
- W2551965620 cites W2010079142 @default.
- W2551965620 cites W2011388270 @default.
- W2551965620 cites W2011753829 @default.
- W2551965620 cites W2013295681 @default.
- W2551965620 cites W2023003596 @default.
- W2551965620 cites W2024551920 @default.
- W2551965620 cites W2026873880 @default.
- W2551965620 cites W2029559005 @default.
- W2551965620 cites W2036326229 @default.
- W2551965620 cites W2038886121 @default.
- W2551965620 cites W2043335239 @default.
- W2551965620 cites W2043624735 @default.
- W2551965620 cites W2045899482 @default.
- W2551965620 cites W2046740266 @default.
- W2551965620 cites W2058288932 @default.
- W2551965620 cites W2058521801 @default.
- W2551965620 cites W2060123496 @default.
- W2551965620 cites W2063399102 @default.
- W2551965620 cites W2067163479 @default.
- W2551965620 cites W2068698763 @default.
- W2551965620 cites W2095111355 @default.
- W2551965620 cites W2104490470 @default.
- W2551965620 cites W2105749330 @default.
- W2551965620 cites W2106008571 @default.
- W2551965620 cites W2109337196 @default.
- W2551965620 cites W2110015307 @default.
- W2551965620 cites W2110737932 @default.
- W2551965620 cites W2117623697 @default.
- W2551965620 cites W2119995710 @default.
- W2551965620 cites W2126851387 @default.
- W2551965620 cites W2132249118 @default.
- W2551965620 cites W2134128560 @default.
- W2551965620 cites W2140754284 @default.
- W2551965620 cites W2141219113 @default.
- W2551965620 cites W2142046859 @default.
- W2551965620 cites W2146843907 @default.
- W2551965620 cites W2150163104 @default.
- W2551965620 cites W2151870437 @default.
- W2551965620 cites W2152091753 @default.
- W2551965620 cites W2158610627 @default.
- W2551965620 cites W2165873626 @default.
- W2551965620 cites W2166478307 @default.
- W2551965620 cites W2171808845 @default.
- W2551965620 cites W2918025614 @default.
- W2551965620 cites W4238966368 @default.
- W2551965620 cites W917998901 @default.
- W2551965620 doi "https://doi.org/10.1038/ncomms13594" @default.
- W2551965620 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5133637" @default.
- W2551965620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27886188" @default.
- W2551965620 hasPublicationYear "2016" @default.
- W2551965620 type Work @default.
- W2551965620 sameAs 2551965620 @default.
- W2551965620 citedByCount "70" @default.
- W2551965620 countsByYear W25519656202017 @default.
- W2551965620 countsByYear W25519656202018 @default.
- W2551965620 countsByYear W25519656202019 @default.
- W2551965620 countsByYear W25519656202020 @default.
- W2551965620 countsByYear W25519656202021 @default.
- W2551965620 countsByYear W25519656202022 @default.
- W2551965620 countsByYear W25519656202023 @default.
- W2551965620 crossrefType "journal-article" @default.
- W2551965620 hasAuthorship W2551965620A5005381760 @default.
- W2551965620 hasAuthorship W2551965620A5008044292 @default.
- W2551965620 hasAuthorship W2551965620A5027272944 @default.