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• W2552001578 abstract "IntroductionElevated interleukin (IL)-6 occurs in patients with active rheumatoid arthritis (RA), which has been shown to lead to a decrease in cytochrome P450 (CYP) enzyme activity and alterations in drug concentrations metabolized by CYP. IL-6 signaling blockade by IL-6 receptor (IL-6R) antagonists may reverse this effect of IL-6 and restore CYP activity. This study evaluated the pharmacokinetic profile of simvastatin (a CYP3A4 substrate) before and 1 week after a single dose of sarilumab (a human monoclonal antibody [mAb] blocking the IL-6Rα) in patients with RA, to assess potential interaction." @default.
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• W2552001578 date "2016-06-01" @default.
• W2552001578 modified "2023-09-28" @default.
• W2552001578 title "AB0184 Disease-Drug Interaction of Sarilumab and Simvastatin in Patients with Rheumatoid Arthritis" @default.
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• W2552001578 doi "https://doi.org/10.1136/annrheumdis-2016-eular.4384" @default.
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