FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2552017299> ?p ?o ?g. }

• W2552017299 endingPage "1565" @default.
• W2552017299 startingPage "1565" @default.
• W2552017299 abstract "Cytokines are key immunoregulatory molecules that regulate T lymphocyte-mediated immune responses and inflammatory reactions. We determined whether there is aberrant expression of interleukin-27 (IL-27) in rheumatoid arthritis (RA) patients and investigated the clinical significance of these changes. IL-27 is a key cellular factor that regulates the differentiation of CD4+ T cells, which can secrete interleukin-10 (IL-10) and interleukin-17 (IL-17) in vivo. Concentrations of serum IL-27 in 67 RA patients, and 36 sex- and age-matched control subjects were measured by enzyme-linked immunosorbent assay (ELISA). Results showed that concentrations of serum IL-27 in all RA patients were significantly higher than in healthy control subjects, and there was a significant and positive correlation between serum IL-27 levels and disease activity in all RA patients. Levels of serum IL-27 in RA patients were significantly correlated with disease activity score in 28 joints (DAS28). Moreover, immunosuppressive treatment with leflunomide downregulated the levels of IL-27 in active RA patients. Therefore, the elevated production of circulating T cell inflammatory factors contributes to the pathogenesis of RA, and serum IL-27 could potentially serve as a new biomarker of RA disease activity." @default.
• W2552017299 created "2016-11-30" @default.
• W2552017299 creator A5009703635 @default.
• W2552017299 creator A5020129476 @default.
• W2552017299 creator A5020732505 @default.
• W2552017299 creator A5048300326 @default.
• W2552017299 creator A5059365254 @default.
• W2552017299 creator A5066375612 @default.
• W2552017299 creator A5067028141 @default.
• W2552017299 date "2016-11-18" @default.
• W2552017299 modified "2023-09-30" @default.
• W2552017299 title "Circulating IL-27 Is Elevated in Rheumatoid Arthritis Patients" @default.
• W2552017299 cites W1919902298 @default.
• W2552017299 cites W1981838374 @default.
• W2552017299 cites W1986370046 @default.
• W2552017299 cites W1986649248 @default.
• W2552017299 cites W1987755713 @default.
• W2552017299 cites W1987847556 @default.
• W2552017299 cites W1989657347 @default.
• W2552017299 cites W1992163151 @default.
• W2552017299 cites W2006053068 @default.
• W2552017299 cites W2016956768 @default.
• W2552017299 cites W2022631529 @default.
• W2552017299 cites W2030306365 @default.
• W2552017299 cites W2034406072 @default.
• W2552017299 cites W2049690086 @default.
• W2552017299 cites W2050451014 @default.
• W2552017299 cites W2054218135 @default.
• W2552017299 cites W2056616552 @default.
• W2552017299 cites W2057522151 @default.
• W2552017299 cites W2058158581 @default.
• W2552017299 cites W2058428161 @default.
• W2552017299 cites W2079077285 @default.
• W2552017299 cites W2097564087 @default.
• W2552017299 cites W2099061596 @default.
• W2552017299 cites W2099433891 @default.
• W2552017299 cites W2101840353 @default.
• W2552017299 cites W2103877708 @default.
• W2552017299 cites W2107933989 @default.
• W2552017299 cites W2108758471 @default.
• W2552017299 cites W2128405329 @default.
• W2552017299 cites W2128728003 @default.
• W2552017299 cites W2131162693 @default.
• W2552017299 cites W2136747946 @default.
• W2552017299 cites W2140657774 @default.
• W2552017299 cites W2141511965 @default.
• W2552017299 cites W2150752051 @default.
• W2552017299 cites W2155923058 @default.
• W2552017299 cites W2162432065 @default.
• W2552017299 cites W2336588424 @default.
• W2552017299 cites W932731813 @default.
• W2552017299 doi "https://doi.org/10.3390/molecules21111565" @default.
• W2552017299 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6273926" @default.
• W2552017299 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27869736" @default.
• W2552017299 hasPublicationYear "2016" @default.
• W2552017299 type Work @default.
• W2552017299 sameAs 2552017299 @default.
• W2552017299 citedByCount "27" @default.
• W2552017299 countsByYear W25520172992017 @default.
• W2552017299 countsByYear W25520172992018 @default.
• W2552017299 countsByYear W25520172992019 @default.
• W2552017299 countsByYear W25520172992020 @default.
• W2552017299 countsByYear W25520172992021 @default.
• W2552017299 countsByYear W25520172992022 @default.
• W2552017299 countsByYear W25520172992023 @default.
• W2552017299 crossrefType "journal-article" @default.
• W2552017299 hasAuthorship W2552017299A5009703635 @default.
• W2552017299 hasAuthorship W2552017299A5020129476 @default.
• W2552017299 hasAuthorship W2552017299A5020732505 @default.
• W2552017299 hasAuthorship W2552017299A5048300326 @default.
• W2552017299 hasAuthorship W2552017299A5059365254 @default.
• W2552017299 hasAuthorship W2552017299A5066375612 @default.
• W2552017299 hasAuthorship W2552017299A5067028141 @default.
• W2552017299 hasBestOaLocation W25520172991 @default.
• W2552017299 hasConcept C11988809 @default.
• W2552017299 hasConcept C126322002 @default.
• W2552017299 hasConcept C150903083 @default.
• W2552017299 hasConcept C203014093 @default.
• W2552017299 hasConcept C207001950 @default.
• W2552017299 hasConcept C26291073 @default.
• W2552017299 hasConcept C2775905006 @default.
• W2552017299 hasConcept C2777077863 @default.
• W2552017299 hasConcept C2777371288 @default.
• W2552017299 hasConcept C2777575956 @default.
• W2552017299 hasConcept C2778690821 @default.
• W2552017299 hasConcept C2780942790 @default.
• W2552017299 hasConcept C2781197716 @default.
• W2552017299 hasConcept C55493867 @default.
• W2552017299 hasConcept C71924100 @default.
• W2552017299 hasConcept C74172505 @default.
• W2552017299 hasConcept C86803240 @default.
• W2552017299 hasConcept C8891405 @default.
• W2552017299 hasConceptScore W2552017299C11988809 @default.
• W2552017299 hasConceptScore W2552017299C126322002 @default.
• W2552017299 hasConceptScore W2552017299C150903083 @default.
• W2552017299 hasConceptScore W2552017299C203014093 @default.
• W2552017299 hasConceptScore W2552017299C207001950 @default.
• W2552017299 hasConceptScore W2552017299C26291073 @default.

• next