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- W2552034221 abstract "Objective: To analyze and compare the gender specific structure profiles of immunoglobulin G(IgG) N-glycans and provide evidence to understand the distribution of the structure of IgG N-glycans in general population. Methods: A cluster sampling was conducted to randomly select 669 participants from Beijing Xuanwu Hospital during January-June 2012. Venous blood sample (5 ml) was collected from each participant with vacuum negative pressure tube containing EDTA. Plasma IgG N-glycome was determined using ultra-performance liquid chromatography (UPLC) on Waters BEH Glycan chromatography column and mass spectrometry after the separation, purification and labeling. Finally, we got 24 chromatographic peaks. Each peak represented a different carbohydrate structure. Independent sample t-test or nonparametric test were used to compare the gender specific difference, P<0.05 was regarded as significant. Results: A total of 669 healthy participants were included, including 235 men (35.13%) and 434 women (64.87%). The average age of the participants was (44.23±9.82) years. The core fucosylation level and the galactosylation level of females were higher than those of males [Fn(Z=-2.192, P=0.028), G0n(Z=-7.898, P<0.001), G1n (Z=-2.343, P=0.019), G2n (Z=-8.414, P<0.001)], but FtotalS1/FtotalS2(Z=-5.049, P<0.001) and FS1/FS2 (Z=-3.336, P=0.001) of females were higher than those of males, indicating a higher saliva acidification level in males than in females. Conclusion: IgG N-glycosylation levels might be gender dependent." @default.
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- W2552034221 date "2016-10-10" @default.
- W2552034221 modified "2023-09-23" @default.
- W2552034221 title "[Comparison of gender specific structure profiles of immunoglobulin G N-glycans]." @default.
- W2552034221 doi "https://doi.org/10.3760/cma.j.issn.0254-6450.2016.10.018" @default.
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