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• W2552053336 abstract "Multiple sclerosis (MS) is characterized by primary inflammation, demyelination, and progressive neurodegeneration. A biochemical MS feature is neuronal mitochondrial dysfunction, compensated by anaerobic metabolism increase, likely aggravating progression of neurodegeneration. Here, we characterized a pragmatic serum profile of compounds related to mitochondrial energy metabolism of potential clinical use. Blood samples of 518 well characterized (disability, disease course) MS patients and 167 healthy controls were analyzed for serum purines, pyrimidines, creatinine, and lactate. Nine of the 15 compounds assayed, hypoxanthine, xanthine, uric acid, inosine, uracil, β-pseudouridine, uridine, creatinine, and lactate, differed significantly between MS patients and controls (p < 0.0001). Using these nine compounds, a unifying Biomarker Score was calculated. Controls and MS patients had mean Biomarker Scores of 0.4 ± 0.7 and 4.4 ± 1.9, respectively (p < 0.00001). The Biomarker Score was higher in patients with progressive (6.0 ± 1.8 than with relapsing remitting disease course (3.6 ± 1.5, p < 0.00001). High association between the Biomarker Score and increase in disability (EDSS) was also observed. Additionally, in 50 patients who underwent magnetic resonance imaging (MRI), increase in the Biomarker Score correlated to neuroanatomical alterations. These results, obtained in a large cohort of MS patients evaluated for serum metabolic compounds connected to energy metabolism, demonstrated that the Biomarker Score might represent a pragmatic, resource saving, easy to obtain, laboratory tool useful to monitor MS patients and predict at an early stage who will switch from an RR to a progressive disease course. For the first time, it was also clearly shown a link between mitochondrial dysfunction and MRI lesions characteristic of MS." @default.
• W2552053336 created "2016-11-30" @default.
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• W2552053336 date "2016-11-08" @default.
• W2552053336 modified "2023-09-30" @default.
• W2552053336 title "Serum Compounds of Energy Metabolism Impairment Are Related to Disability, Disease Course and Neuroimaging in Multiple Sclerosis" @default.
• W2552053336 cites W1480277763 @default.
• W2552053336 cites W1498875382 @default.
• W2552053336 cites W153101962 @default.
• W2552053336 cites W1599893459 @default.
• W2552053336 cites W1650328097 @default.
• W2552053336 cites W1741394649 @default.
• W2552053336 cites W1852530796 @default.
• W2552053336 cites W1902868253 @default.
• W2552053336 cites W1952038492 @default.
• W2552053336 cites W1963589394 @default.
• W2552053336 cites W1966705207 @default.
• W2552053336 cites W1967203590 @default.
• W2552053336 cites W1967985070 @default.
• W2552053336 cites W1968087983 @default.
• W2552053336 cites W1969939093 @default.
• W2552053336 cites W1973759319 @default.
• W2552053336 cites W1976180304 @default.
• W2552053336 cites W1977490008 @default.
• W2552053336 cites W1985740655 @default.
• W2552053336 cites W1988951836 @default.
• W2552053336 cites W1998210176 @default.
• W2552053336 cites W2001355603 @default.
• W2552053336 cites W2002629623 @default.
• W2552053336 cites W2003674170 @default.
• W2552053336 cites W2009094537 @default.
• W2552053336 cites W2011071409 @default.
• W2552053336 cites W2013234597 @default.
• W2552053336 cites W2017923417 @default.
• W2552053336 cites W2025460536 @default.
• W2552053336 cites W2032650268 @default.
• W2552053336 cites W2034541814 @default.
• W2552053336 cites W2035159408 @default.
• W2552053336 cites W2036337813 @default.
• W2552053336 cites W2040989443 @default.
• W2552053336 cites W2044588294 @default.
• W2552053336 cites W2045281690 @default.
• W2552053336 cites W2047236390 @default.
• W2552053336 cites W2048088159 @default.
• W2552053336 cites W2059164443 @default.
• W2552053336 cites W2062885725 @default.
• W2552053336 cites W2066059319 @default.
• W2552053336 cites W2070365230 @default.
• W2552053336 cites W2072441398 @default.
• W2552053336 cites W2073833993 @default.
• W2552053336 cites W2074464138 @default.
• W2552053336 cites W2075446533 @default.
• W2552053336 cites W2077035149 @default.
• W2552053336 cites W2078521579 @default.
• W2552053336 cites W2080090922 @default.
• W2552053336 cites W2086423038 @default.
• W2552053336 cites W2087589796 @default.
• W2552053336 cites W2087968417 @default.
• W2552053336 cites W2099253391 @default.
• W2552053336 cites W2100283192 @default.
• W2552053336 cites W2105008687 @default.
• W2552053336 cites W2112165124 @default.
• W2552053336 cites W2118651750 @default.
• W2552053336 cites W2127147704 @default.
• W2552053336 cites W2142577589 @default.
• W2552053336 cites W2143953700 @default.
• W2552053336 cites W2154431665 @default.
• W2552053336 cites W2160504750 @default.
• W2552053336 cites W2162521648 @default.
• W2552053336 cites W2162978315 @default.
• W2552053336 cites W2165481371 @default.
• W2552053336 cites W2169857962 @default.
• W2552053336 cites W2171558385 @default.
• W2552053336 cites W2173194334 @default.
• W2552053336 cites W2175008736 @default.
• W2552053336 cites W2183230425 @default.
• W2552053336 cites W2187022809 @default.
• W2552053336 cites W2210039948 @default.
• W2552053336 cites W2231157493 @default.
• W2552053336 cites W2272462464 @default.
• W2552053336 cites W2328896914 @default.
• W2552053336 cites W2916040650 @default.
• W2552053336 cites W4211254511 @default.
• W2552053336 cites W937088433 @default.
• W2552053336 doi "https://doi.org/10.1007/s12035-016-0257-9" @default.
• W2552053336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27826747" @default.
• W2552053336 hasPublicationYear "2016" @default.
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• W2552053336 citedByCount "42" @default.

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