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- W2552056598 abstract "Background At the present time remission is the target for treatment of rheumatoid arthritis (RA). Various composite indices are available that can be used to define remission. Although the new ACR/EULAR Boolean criteria is more stringent than others, it is difficult to achieve and even more difficult to sustain this Boolean remission. Objectives In this study we aimed to determine the differences of the ultrasonographically (US) assessed actual disease activities of the patients in remission according to different remission criteria. Methods RA patients in clinical remission (DAS28-ESR Results A total of 88 out of 389 RA patients (22.6%) in DAS28 remission were enrolled (F/M=55/33, mean age 53.4±12.0, disease duration 10.5±6.3 years, bDMARDs 44.3%, RF/Anti-CCP positivity 72%). Of the 88 patients, 82 (93.2%), 72 (81.8%), 49 (55.7%), 40 (45.5%) and 33 (37.5%) fulfilled the DAS28-CRP, DAS28-ESR-3, SDAI, CDAI and Boolean remission criteria, respectively. PD synovitis scores which have shown to be associated with erosion development and worse functional outcome were lowest in CDAI, Boolean and SDAI remission. However despite that, those differences in US disease activity parameters (both PD and GS synovitis sum scores and percentages of patients without PD and GS signals [with both omitting and including grade 1 signals]) in remission patients according to different criteria were not statistically significant ( Table 1 ). In comparison of US disease activity parameters of remission vs nonremission groups, only patients with Boolean and CDAI remission had significantly lower PD scores compared to their counterpart nonremission group (for both, 1 [0–4] vs 3 [1–7], P =0.015). Conclusions US verified joint inflammation is the lowest in RA patients who are in remission according to Boolean and CDAI criteria. However, the clinical significance of this statistically nonsignificant inflammatory activity compared to other clinical remission criteria should be assessed in prospective studies. Till then, in clinical practice if Boolean remission could not be achieved, CDAI or SDAI could also be preferred as the remission target. Disclosure of Interest None declared" @default.
- W2552056598 created "2016-11-30" @default.
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- W2552056598 date "2016-06-01" @default.
- W2552056598 modified "2023-10-18" @default.
- W2552056598 title "FRI0531 Differences in Ultrasonographic Disease Activity in Rheumatoid Arthritis Patients Who Are in Clinical Remission According To Different Remission Criteria" @default.
- W2552056598 doi "https://doi.org/10.1136/annrheumdis-2016-eular.1542" @default.
- W2552056598 hasPublicationYear "2016" @default.
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