FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2552087653> ?p ?o ?g. }

• W2552087653 endingPage "527" @default.
• W2552087653 startingPage "526.3" @default.
• W2552087653 abstract "<h3>Background</h3> There is an increased appreciation of the burden of cognitive impairment in people with autoimmune diseases (1). Recent studies have demonstrated that patients with systemic sclerosis (SSc) have a specific pattern of cognitive impairment: the dysexecutive syndrome (2). <h3>Objectives</h3> We evaluated the prevalence of cognitive impairment in SSc and assessed the association with the disease features and impact on daily living <h3>Methods</h3> Consecutive SSc from EUSTAR center 096 were examined. Montreal Cognitive Assessment (MoCA) was used to assess cognitive dysfunction and scores ≤26 were considered abnormal (3). SSc patients were assessed according tu MEDS evaluation sheets to determine organ involvement, autoantibody profile, disease activity (Valentine Activity Index) and disease severity (Medsger Severity Index). sHAQ (Scleroderma Health Assessment Questionnaire) has also been completed. Data were compared by difference tests according to the types of variables: t-test, Mann-Whitney or chi-square. To evaluate correlations between variables Pearson or Spearman correlations were used. <h3>Results</h3> A total of 70 SSc patients [36 (51.42%) limited SSc (lSSc) and 34 (48.57%) with diffuse SSc (dSSc), 60 female; mean age 54.5 (±11.62) years; mean disease duration 66 (±429.6) months] were included in the study. 47.14% of the patients had active disease, the mean Rodnan score was 7 (±4.17), the mean Medsger score was 5.5 (±2.89), 24.28% of the patients had lung involvement and 20% had pulmonary arterial hypertension. The mean HAQ was 1 (±0.59). Cognitive impairment was identified in 65.71% SSc patients; the mean MOCA score was 26 (±2.83). Cognitive impairment of SSc patients was related to older age (r=-0.378, p=0.001), rural provenience (r=-0.351,p=0.003), severity of the disease evaluated by the Medsger score (r=–0.262,p=0.029) and poor quality of life evaluated by sHAQ (r=-0.323,p=0.003).Correlations were also identified with musculoarticular involvement (r=-0.330,p=0.006), advanced capillaroscopy patttern (r=-0.331, p=0.006). The diiffuse SSc patients were more likely to have cognitive dysfunction (likehood ratio 0.012) as were those with SCL70 positive (0.0.18). No relationship was identified between cognitive impairment and lung, heart or renal involvement, the presence of digital ulcers, the use of corticosteoids or immunosuppression. <h3>Conclusions</h3> An increased prevalence of cognitive impairment was observed in SSc and associated with age, rural provenience, more severe disease, muscle involvement and poor quality of life. Further studies are needed to be compared with healthy controls and to assess the role of microvascular damage or that of other confounders. <h3>References</h3> T.N.Amaral et al. Prevalence and significance of cognitive impairment in systemic sclerosis Ann Rheum Dis 2015;74:605 Ylmaz N. et al Dysexecutive syndrome: a specific pattern of cognitive impairment in systemic sclerosis Cogn Behav Neurol. 2012 Jun;25(2):57–62. www.mocatest.org/normative-data/ <h3>Disclosure of Interest</h3> None declared" @default.
• W2552087653 created "2016-11-30" @default.
• W2552087653 creator A5006976812 @default.
• W2552087653 creator A5015186627 @default.
• W2552087653 creator A5025225815 @default.
• W2552087653 creator A5039591921 @default.
• W2552087653 creator A5045567155 @default.
• W2552087653 creator A5046322276 @default.
• W2552087653 creator A5066521345 @default.
• W2552087653 creator A5067343263 @default.
• W2552087653 creator A5072865266 @default.
• W2552087653 creator A5073135743 @default.
• W2552087653 creator A5076890497 @default.
• W2552087653 creator A5081895619 @default.
• W2552087653 creator A5084235536 @default.
• W2552087653 creator A5089822409 @default.
• W2552087653 date "2016-06-01" @default.
• W2552087653 modified "2023-10-17" @default.
• W2552087653 title "FRI0256 Significance of Cognitive Impairment in Systemic Sclerosis" @default.
• W2552087653 doi "https://doi.org/10.1136/annrheumdis-2016-eular.5190" @default.
• W2552087653 hasPublicationYear "2016" @default.
• W2552087653 type Work @default.
• W2552087653 sameAs 2552087653 @default.
• W2552087653 citedByCount "2" @default.
• W2552087653 countsByYear W25520876532020 @default.
• W2552087653 countsByYear W25520876532023 @default.
• W2552087653 crossrefType "journal-article" @default.
• W2552087653 hasAuthorship W2552087653A5006976812 @default.
• W2552087653 hasAuthorship W2552087653A5015186627 @default.
• W2552087653 hasAuthorship W2552087653A5025225815 @default.
• W2552087653 hasAuthorship W2552087653A5039591921 @default.
• W2552087653 hasAuthorship W2552087653A5045567155 @default.
• W2552087653 hasAuthorship W2552087653A5046322276 @default.
• W2552087653 hasAuthorship W2552087653A5066521345 @default.
• W2552087653 hasAuthorship W2552087653A5067343263 @default.
• W2552087653 hasAuthorship W2552087653A5072865266 @default.
• W2552087653 hasAuthorship W2552087653A5073135743 @default.
• W2552087653 hasAuthorship W2552087653A5076890497 @default.
• W2552087653 hasAuthorship W2552087653A5081895619 @default.
• W2552087653 hasAuthorship W2552087653A5084235536 @default.
• W2552087653 hasAuthorship W2552087653A5089822409 @default.
• W2552087653 hasConcept C118552586 @default.
• W2552087653 hasConcept C126322002 @default.
• W2552087653 hasConcept C169900460 @default.
• W2552087653 hasConcept C1862650 @default.
• W2552087653 hasConcept C198451711 @default.
• W2552087653 hasConcept C2776632958 @default.
• W2552087653 hasConcept C2779134260 @default.
• W2552087653 hasConcept C2984915365 @default.
• W2552087653 hasConcept C71924100 @default.
• W2552087653 hasConceptScore W2552087653C118552586 @default.
• W2552087653 hasConceptScore W2552087653C126322002 @default.
• W2552087653 hasConceptScore W2552087653C169900460 @default.
• W2552087653 hasConceptScore W2552087653C1862650 @default.
• W2552087653 hasConceptScore W2552087653C198451711 @default.
• W2552087653 hasConceptScore W2552087653C2776632958 @default.
• W2552087653 hasConceptScore W2552087653C2779134260 @default.
• W2552087653 hasConceptScore W2552087653C2984915365 @default.
• W2552087653 hasConceptScore W2552087653C71924100 @default.
• W2552087653 hasIssue "Suppl 2" @default.
• W2552087653 hasLocation W25520876531 @default.
• W2552087653 hasOpenAccess W2552087653 @default.
• W2552087653 hasPrimaryLocation W25520876531 @default.
• W2552087653 hasRelatedWork W2349885465 @default.
• W2552087653 hasRelatedWork W2355010744 @default.
• W2552087653 hasRelatedWork W2365657003 @default.
• W2552087653 hasRelatedWork W2371310385 @default.
• W2552087653 hasRelatedWork W2378610969 @default.
• W2552087653 hasRelatedWork W2384210696 @default.
• W2552087653 hasRelatedWork W2388988339 @default.
• W2552087653 hasRelatedWork W2391419718 @default.
• W2552087653 hasRelatedWork W2392742346 @default.
• W2552087653 hasRelatedWork W8492557 @default.
• W2552087653 hasVolume "75" @default.
• W2552087653 isParatext "false" @default.
• W2552087653 isRetracted "false" @default.
• W2552087653 magId "2552087653" @default.
• W2552087653 workType "article" @default.