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• W2552111244 abstract "Abstract Nitidine chloride (NC), a bioactive alkaloid isolated from Zanthoxylum nitidum , has been used as a herbal ingredient in toothpaste that prevents cavities for decades. It also displays potential antitumor and anti-inflammation properties. However, its anticatabolic effect on bone is not known. We investigated the effect of NC on osteoclastogenesis, bone resorption and RANKL-induced NF-κB and NFATc1 signalling. In mouse-derived bone marrow monocytes (BMMs), NC suppressed RANKL-induced multinucleated tartrate-resistant acid phosphatase (TRAP)-positive osteoclast formation and bone resorption in a dose dependent manner. NC attenuated the expression of osteoclast marker genes including cathepsin K, D2, calcitonin receptor, NFATc1, and TRAP. Further, NC inhibited RANKL-activated NF-κB and NFATc1 signalling pathways. In vivo study revealed that NC abrogated oestrogen deficiency-induced bone loss in ovariectomized mice. Histological analysis showed that the number of osteoclasts was significantly lower in NC-treated groups. Collectively, our data demonstrate that NC suppressed osteoclastogenesis and prevented OVX-induced bone loss by inhibiting RANKL-induced NF-κB and NFATc1 signalling pathways. NC may be a natural and novel treatment for osteoclast-related bone lytic diseases." @default.
• W2552111244 created "2016-11-30" @default.
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• W2552111244 date "2016-11-08" @default.
• W2552111244 modified "2023-09-26" @default.
• W2552111244 title "Nitidine chloride prevents OVX-induced bone loss via suppressing NFATc1-mediated osteoclast differentiation" @default.
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• W2552111244 doi "https://doi.org/10.1038/srep36662" @default.
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