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- W2552149128 abstract "Burkitt lymphoma (BL) is a highly aggressive B-cell malignancy, occurring with increased frequency among patients infected with HIV. For several years, the immunocompromised state of HIV-positive patients was advocated as a sufficient reason to avoid the intensive chemotherapeutic regimens used in HIV-negative BL. However, with the introduction of the highly active antiretroviral therapy (HAART), the subsequent improvement of the immunological state of HIV-positive patients, and the disappointing results of less intensive schedules, investigators began to apply the same chemotherapeutic regimens used as a gold standard in HIV-negative non-Hodgkin lymphoma (NHL), including the use of rituximab. Despite promising results of different schedules in early-phase studies, agreement on the treatment of HIV-positive BL is still lacking, and further trials are needed to define a standard of care. Moreover, new treatment frontiers need to focus on improving the outcome for patients with advanced immunosuppression, unfavourable prognostic features- such as advanced stages and high International Prognostic Index (IPI) scores – and for those with adverse tumour biology. This paper aims to revise the main epidemiological and physiopathological features of HIV-positive BL, to summarise the most relevant steps in the treatment of affected patients, and to elucidate the role of HAART in allowing HIV-positive patients to be managed with the therapeutic strategies currently used in HIV-negative patients with BL." @default.
- W2552149128 created "2016-11-30" @default.
- W2552149128 creator A5031300985 @default.
- W2552149128 creator A5031391013 @default.
- W2552149128 creator A5085410438 @default.
- W2552149128 date "2013-08-01" @default.
- W2552149128 modified "2023-09-25" @default.
- W2552149128 title "Treatment of HIV-Associated Burkitt Lymphoma" @default.
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- W2552149128 doi "https://doi.org/10.33590/emjhematol/10310781" @default.
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