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- W2552205344 abstract "Introduction Dual bronchodilators provide greater improvements in lung function vs monotherapy in patients with COPD. Here we investigated whether dual bronchodilation improved the St George9s Respiratory Questionnaire (SGRQ) domain scores vs monotherapy. Methods This was a post hoc pooled analysis of three 6-month, blinded, Phase III studies of umeclidinium/vilanterol (UMEC/VI, 62.5/25 mcg; ELLIPTA™) and tiotropium (TIO, 18 mcg; HandiHaler®) in patients with COPD. Outcomes included SGRQ total and domain scores (Activity, Symptoms and Impacts). Analyses were performed using a repeated measures model. Results Overall, 878 patients received UMEC/VI and 869 TIO. SGRQ score by domain and total SGRQ score at Days 28 and 168 are presented in the table. Conclusion While clinically significant improvements in health status were reported in both treatment arms, dual bronchodilation with UMEC/VI provided statistical improvements vs TIO monotherapy in total SGRQ score and in each of its domains at Day 28 and in the Symptoms domain at Day 168. Funded by GSK (ZEP117115 [NCT01777334], DB2113374 [NCT01316913], DB2113360 [NCT01316900]; 202066)." @default.
- W2552205344 created "2016-11-30" @default.
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- W2552205344 date "2016-09-01" @default.
- W2552205344 modified "2023-09-23" @default.
- W2552205344 title "Treatment effect of umeclidinium/vilanterol and tiotropium on SGRQ sub-domains" @default.
- W2552205344 doi "https://doi.org/10.1183/13993003.congress-2016.pa312" @default.
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