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• W2552207323 abstract "// Nazim Benzerdjeb 1, 2 , Henri Sevestre 2 , Ahmed Ahidouch 2, 3 , Halima Ouadid-Ahidouch 1 1 Laboratory of Cellular and Molecular Physiology, LPCM: EA 4667, SFR CAP-SANTE (FED 4231), UFR of Sciences, Amiens, France 2 Department of Pathology, Amiens University Hospital, Amiens, France 3 Department of Biology, Ibn Zohr University, Agadir, Morocco Correspondence to: Halima Ouadid-Ahidouch, email: halima.ahidouch-ouadid@u-picardie.fr Nazim Benzerdjeb, email: nazim.benz@gmail.com Keywords: orai3, lung adenocarcinoma, prognostic marker, survival Received: June 11, 2016     Accepted: October 17, 2016     Published: November 07, 2016 ABSTRACT Orai3 channel has emerged as important player in malignant transformation. Indeed, its expression is increased in cancer and favors cell proliferation and survival by permitting calcium influx. In this study, Orai3 was overexpressed in lung adenocarcinoma as compared to their matched non-tumour samples and was associated with tumoural aggressiveness. Moreover, its expression was associated with estrogen receptor alpha (ERα) expression and visceral pleural invasion in multivariate analysis. Furthermore, both the overall survival (OS) median and the metastasis free survival (MFS) median of tumors with high Orai3 expression were lower than in low Orai3 expression regardless of cancer stage (35.01 months vs. 51.11 months for OS and 46.01 months vs. 62.04 months for MFS). In conclusion, Orai3 protein level constitutes an independent prognostic marker in lung adenocarcinoma, and a novel prognostic marker that could help selecting the patients with worst prognosis to be treated with adjuvant chemotherapy in resectable stage." @default.
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• W2552207323 date "2016-11-07" @default.
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• W2552207323 title "Orai3 is a predictive marker of metastasis and survival in resectable lung adenocarcinoma" @default.
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• W2552207323 doi "https://doi.org/10.18632/oncotarget.13149" @default.
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