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- W2552237962 abstract "Drug delivery systems with targeting agents for precise drug release in cancer therapy are very significant and important. Herein, we report the rational design and synthesis of a DOX (doxorubicin) loaded UiO-68-type of nanoscale metal-organic framework (NMOF) with a tumor targeting agent (folic acid, FA), DOX@UiO-68-FA (3), as a multifunctional drug delivery system for hepatoma (Hep G2) therapy via tail-vein injection. Compared to free DOX, FA-unloaded DOX@Mi-UiO-68 (2), 3 exhibits a much higher antitumor efficacy, which was confirmed by cell imaging, standard 3-(4,5-dimethylthiahiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) proliferation and in vivo experiments." @default.
- W2552237962 created "2016-11-30" @default.
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- W2552237962 date "2016-01-01" @default.
- W2552237962 modified "2023-10-03" @default.
- W2552237962 title "A drug-loaded nanoscale metal–organic framework with a tumor targeting agent for highly effective hepatoma therapy" @default.
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- W2552237962 doi "https://doi.org/10.1039/c6cc07321b" @default.
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