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- W2552238761 abstract "Abstract Nucleotide excision repair and the ATR ‐mediated DNA damage checkpoint are two critical cellular responses to the genotoxic stress induced by ultraviolet ( UV ) light and are important for cancer prevention. In vivo genetic data indicate that these global responses are coupled. Aziz Sancar et al . developed an in vitro coupled repair‐checkpoint system to analyze the basic steps of these DNA damage stress responses in a biochemically defined system. The minimum set of factors essential for repair‐checkpoint coupling include damaged DNA , the excision repair factors ( XPA , XPC , XPF ‐ ERCC 1, XPG , TFIIH , RPA ), the 5′‐3′ exonuclease EXO 1, and the damage checkpoint proteins ATR ‐ ATRIP and Top BP 1. This coupled repair‐checkpoint system was used to demonstrate that the ~30 nucleotide single‐stranded DNA (ss DNA ) gap generated by nucleotide excision repair is enlarged by EXO 1 and bound by RPA to generate the signal that activates ATR ." @default.
- W2552238761 created "2016-11-30" @default.
- W2552238761 creator A5005229561 @default.
- W2552238761 date "2016-12-28" @default.
- W2552238761 modified "2023-10-03" @default.
- W2552238761 title "Bringing It All Together: Coupling Excision Repair to the DNA Damage Checkpoint" @default.
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- W2552238761 doi "https://doi.org/10.1111/php.12667" @default.
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