Matches in SemOpenAlex for { <https://semopenalex.org/work/W2552263104> ?p ?o ?g. }
- W2552263104 endingPage "137" @default.
- W2552263104 startingPage "125" @default.
- W2552263104 abstract "Abstract In eukaryotic cells, the organization of genomic DNA into chromatin regulates many biological processes, from the control of gene expression to the regulation of chromosome segregation. The proper maintenance of this structure upon cell division is therefore of prime importance during development for the maintenance of cell identity and genome stability. The chromatin assembly factor 1 (CAF-1) is involved in the assembly of H3-H4 histone dimers on newly synthesized DNA and in the maintenance of a higher order structure, the heterochromatin, through an interaction of its large subunit with the heterochromatin protein HP1a. We identify here a conserved domain in the large subunit of the CAF-1 complex required for its interaction with HP1a in the Drosophila fruit fly. Functional analysis reveals that this domain is dispensable for viability but participates in two processes involving heterochromatin: position-effect variegation and long range chromosomal interactions during meiotic prophase. Importantly, the identification in the large subunit of CAF-1 of a domain required for its interaction with HP1 allows the separation of its functions in heterochromatin-related processes from its function in the assembly of H3-H4 dimers onto newly synthesized DNA." @default.
- W2552263104 created "2016-11-30" @default.
- W2552263104 creator A5004329264 @default.
- W2552263104 creator A5024509524 @default.
- W2552263104 creator A5047800178 @default.
- W2552263104 creator A5077987869 @default.
- W2552263104 creator A5087957636 @default.
- W2552263104 date "2017-01-01" @default.
- W2552263104 modified "2023-10-13" @default.
- W2552263104 title "Maintenance of Heterochromatin by the Large Subunit of the CAF-1 Replication-Coupled Histone Chaperone Requires Its Interaction with HP1a Through a Conserved Motif" @default.
- W2552263104 cites W1040360261 @default.
- W2552263104 cites W1519266993 @default.
- W2552263104 cites W1856601345 @default.
- W2552263104 cites W1917475571 @default.
- W2552263104 cites W1964541915 @default.
- W2552263104 cites W1976121220 @default.
- W2552263104 cites W1992763575 @default.
- W2552263104 cites W1993968374 @default.
- W2552263104 cites W2003848087 @default.
- W2552263104 cites W2009238064 @default.
- W2552263104 cites W2019542560 @default.
- W2552263104 cites W2019600152 @default.
- W2552263104 cites W2027365572 @default.
- W2552263104 cites W2030299752 @default.
- W2552263104 cites W2033828311 @default.
- W2552263104 cites W2035424802 @default.
- W2552263104 cites W2038661934 @default.
- W2552263104 cites W2039055983 @default.
- W2552263104 cites W2047746027 @default.
- W2552263104 cites W2049145056 @default.
- W2552263104 cites W2050691074 @default.
- W2552263104 cites W2052540561 @default.
- W2552263104 cites W2057185906 @default.
- W2552263104 cites W2057664390 @default.
- W2552263104 cites W2068068198 @default.
- W2552263104 cites W2068690942 @default.
- W2552263104 cites W2069378046 @default.
- W2552263104 cites W2072361233 @default.
- W2552263104 cites W2077595353 @default.
- W2552263104 cites W2080791829 @default.
- W2552263104 cites W2087985833 @default.
- W2552263104 cites W2094431101 @default.
- W2552263104 cites W2096501951 @default.
- W2552263104 cites W2101092089 @default.
- W2552263104 cites W2102032416 @default.
- W2552263104 cites W2108116072 @default.
- W2552263104 cites W2110643873 @default.
- W2552263104 cites W2117438690 @default.
- W2552263104 cites W2124670713 @default.
- W2552263104 cites W2127316404 @default.
- W2552263104 cites W2128574405 @default.
- W2552263104 cites W2129301466 @default.
- W2552263104 cites W2132109794 @default.
- W2552263104 cites W2132926880 @default.
- W2552263104 cites W2133118702 @default.
- W2552263104 cites W2143190270 @default.
- W2552263104 cites W2143681892 @default.
- W2552263104 cites W2146295682 @default.
- W2552263104 cites W2151840993 @default.
- W2552263104 cites W2154189007 @default.
- W2552263104 cites W2156875872 @default.
- W2552263104 cites W2163184765 @default.
- W2552263104 cites W2297569848 @default.
- W2552263104 cites W2417114846 @default.
- W2552263104 cites W81366906 @default.
- W2552263104 doi "https://doi.org/10.1534/genetics.116.190785" @default.
- W2552263104 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5223498" @default.
- W2552263104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27838630" @default.
- W2552263104 hasPublicationYear "2017" @default.
- W2552263104 type Work @default.
- W2552263104 sameAs 2552263104 @default.
- W2552263104 citedByCount "7" @default.
- W2552263104 countsByYear W25522631042017 @default.
- W2552263104 countsByYear W25522631042018 @default.
- W2552263104 countsByYear W25522631042019 @default.
- W2552263104 countsByYear W25522631042020 @default.
- W2552263104 crossrefType "journal-article" @default.
- W2552263104 hasAuthorship W2552263104A5004329264 @default.
- W2552263104 hasAuthorship W2552263104A5024509524 @default.
- W2552263104 hasAuthorship W2552263104A5047800178 @default.
- W2552263104 hasAuthorship W2552263104A5077987869 @default.
- W2552263104 hasAuthorship W2552263104A5087957636 @default.
- W2552263104 hasBestOaLocation W25522631041 @default.
- W2552263104 hasConcept C103435993 @default.
- W2552263104 hasConcept C104317684 @default.
- W2552263104 hasConcept C148196450 @default.
- W2552263104 hasConcept C30481170 @default.
- W2552263104 hasConcept C45413362 @default.
- W2552263104 hasConcept C54355233 @default.
- W2552263104 hasConcept C552990157 @default.
- W2552263104 hasConcept C63491729 @default.
- W2552263104 hasConcept C64927066 @default.
- W2552263104 hasConcept C83640560 @default.
- W2552263104 hasConcept C86803240 @default.
- W2552263104 hasConcept C92149661 @default.
- W2552263104 hasConcept C95444343 @default.
- W2552263104 hasConceptScore W2552263104C103435993 @default.
- W2552263104 hasConceptScore W2552263104C104317684 @default.