FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2552273856> ?p ?o ?g. }

• W2552273856 endingPage "441" @default.
• W2552273856 startingPage "441" @default.
• W2552273856 abstract "Proc Amer Assoc Cancer Res, Volume 46, 20051883 The ATM gene is mutated in ataxia-telangiectasia (A-T). Female A-T heterozygotes have a 2-7 fold increased risk of breast cancer. We previously reported high risk associations between certain ATM variants and breast cancer. In order to estimate the risks of breast cancer associated with ATM variants more precisely, we have examined two ATM variants, IVS10-6T>G and 1420L>F, in additional cases and controls from the same Australian cohorts previously used to estimate the risk of breast cancer associated with IVS10-6T>G. A total of 775 and 84 population-based controls were genotyped for the IVS10-6T>G and 1420L>F ATM variants respectively, as were index cases from 378 and 373 non-BRCA1 /2 breast cancer families. Penetrance was estimated by Bayes factor analysis. The allele frequencies of ATM IVS10-6T>G and 1420L>F estimated from controls were 0.005 (95% CI = 0.002 to 0.009) and 0.012 (95% CI = 0.001 to 0.042) respectively. We identified three new multiple-case breast cancer families with ATM IVS10-6T>G, and seven families with 1420L>F. Combining with the two IVS10-6T>G families previously reported, the estimated penetrance to age 70 of IVS10-6T>G was 17.2% (95% CI = 4.7% to 37.5%). For 1420L>F, the estimated average penetrance was 4.8% (95% CI 1.7% to 10.1%). In conclusion, we found no evidence that the ATM 1420L>F variant increases breast cancer risk, and little evidence that IVS10-6T>G confers an elevated risk. Analysis of additional families will be necessary to define more precisely the risk, if any, associated with IVS10-6T>G. ." @default.
• W2552273856 created "2016-11-30" @default.
• W2552273856 creator A5006870605 @default.
• W2552273856 creator A5007290231 @default.
• W2552273856 creator A5010709642 @default.
• W2552273856 creator A5016337859 @default.
• W2552273856 creator A5020047388 @default.
• W2552273856 creator A5023667273 @default.
• W2552273856 creator A5034946189 @default.
• W2552273856 creator A5038773254 @default.
• W2552273856 creator A5040784242 @default.
• W2552273856 creator A5049698906 @default.
• W2552273856 creator A5052977796 @default.
• W2552273856 creator A5054360713 @default.
• W2552273856 creator A5058896759 @default.
• W2552273856 creator A5069535362 @default.
• W2552273856 creator A5081742830 @default.
• W2552273856 date "2005-05-01" @default.
• W2552273856 modified "2023-09-23" @default.
• W2552273856 title "Two ATM variants, IVS10-6T>G and 1420L>F, and breast cancer risk" @default.
• W2552273856 hasPublicationYear "2005" @default.
• W2552273856 type Work @default.
• W2552273856 sameAs 2552273856 @default.
• W2552273856 citedByCount "0" @default.
• W2552273856 crossrefType "journal-article" @default.
• W2552273856 hasAuthorship W2552273856A5006870605 @default.
• W2552273856 hasAuthorship W2552273856A5007290231 @default.
• W2552273856 hasAuthorship W2552273856A5010709642 @default.
• W2552273856 hasAuthorship W2552273856A5016337859 @default.
• W2552273856 hasAuthorship W2552273856A5020047388 @default.
• W2552273856 hasAuthorship W2552273856A5023667273 @default.
• W2552273856 hasAuthorship W2552273856A5034946189 @default.
• W2552273856 hasAuthorship W2552273856A5038773254 @default.
• W2552273856 hasAuthorship W2552273856A5040784242 @default.
• W2552273856 hasAuthorship W2552273856A5049698906 @default.
• W2552273856 hasAuthorship W2552273856A5052977796 @default.
• W2552273856 hasAuthorship W2552273856A5054360713 @default.
• W2552273856 hasAuthorship W2552273856A5058896759 @default.
• W2552273856 hasAuthorship W2552273856A5069535362 @default.
• W2552273856 hasAuthorship W2552273856A5081742830 @default.
• W2552273856 hasConcept C104317684 @default.
• W2552273856 hasConcept C121608353 @default.
• W2552273856 hasConcept C126322002 @default.
• W2552273856 hasConcept C127716648 @default.
• W2552273856 hasConcept C143425029 @default.
• W2552273856 hasConcept C143998085 @default.
• W2552273856 hasConcept C180754005 @default.
• W2552273856 hasConcept C200544954 @default.
• W2552273856 hasConcept C2779486608 @default.
• W2552273856 hasConcept C2908647359 @default.
• W2552273856 hasConcept C530470458 @default.
• W2552273856 hasConcept C54355233 @default.
• W2552273856 hasConcept C552990157 @default.
• W2552273856 hasConcept C71924100 @default.
• W2552273856 hasConcept C86803240 @default.
• W2552273856 hasConcept C99454951 @default.
• W2552273856 hasConceptScore W2552273856C104317684 @default.
• W2552273856 hasConceptScore W2552273856C121608353 @default.
• W2552273856 hasConceptScore W2552273856C126322002 @default.
• W2552273856 hasConceptScore W2552273856C127716648 @default.
• W2552273856 hasConceptScore W2552273856C143425029 @default.
• W2552273856 hasConceptScore W2552273856C143998085 @default.
• W2552273856 hasConceptScore W2552273856C180754005 @default.
• W2552273856 hasConceptScore W2552273856C200544954 @default.
• W2552273856 hasConceptScore W2552273856C2779486608 @default.
• W2552273856 hasConceptScore W2552273856C2908647359 @default.
• W2552273856 hasConceptScore W2552273856C530470458 @default.
• W2552273856 hasConceptScore W2552273856C54355233 @default.
• W2552273856 hasConceptScore W2552273856C552990157 @default.
• W2552273856 hasConceptScore W2552273856C71924100 @default.
• W2552273856 hasConceptScore W2552273856C86803240 @default.
• W2552273856 hasConceptScore W2552273856C99454951 @default.
• W2552273856 hasLocation W25522738561 @default.
• W2552273856 hasOpenAccess W2552273856 @default.
• W2552273856 hasPrimaryLocation W25522738561 @default.
• W2552273856 hasRelatedWork W1427913268 @default.
• W2552273856 hasRelatedWork W1921760177 @default.
• W2552273856 hasRelatedWork W1983920609 @default.
• W2552273856 hasRelatedWork W2004096216 @default.
• W2552273856 hasRelatedWork W2101291606 @default.
• W2552273856 hasRelatedWork W2122153648 @default.
• W2552273856 hasRelatedWork W2172198403 @default.
• W2552273856 hasRelatedWork W2184867989 @default.
• W2552273856 hasRelatedWork W2333436290 @default.
• W2552273856 hasRelatedWork W2350419218 @default.
• W2552273856 hasRelatedWork W2371112117 @default.
• W2552273856 hasRelatedWork W2561039102 @default.
• W2552273856 hasRelatedWork W2608818514 @default.
• W2552273856 hasRelatedWork W2748006448 @default.
• W2552273856 hasRelatedWork W2888625159 @default.
• W2552273856 hasRelatedWork W2934528750 @default.
• W2552273856 hasRelatedWork W2940808606 @default.
• W2552273856 hasRelatedWork W3009815779 @default.
• W2552273856 hasRelatedWork W3044007276 @default.
• W2552273856 hasRelatedWork W3146834886 @default.
• W2552273856 hasVolume "65" @default.
• W2552273856 isParatext "false" @default.
• W2552273856 isRetracted "false" @default.

• next