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- W2552290841 abstract "Zoledronate is a highly potent bisphosphonate widely used in the treatment of postmenopausal osteoporosis. We report the first occurrence of toxic acute tubular necrosis (ATN) following treatment with zoledronate in a patient with osteoporosis. A 63-year-old Caucasian female with rheumatoid arthritis on anti-immune agents received a single dose of zoledronic acid (reclast) for worsening osteoporosis. Twelve days later, she developed renal failure with a rise in serum creatinine from a baseline level of 1.1 mg/dL to 5.5 mg/dL. Renal biopsy showed toxic ATN. Zoledronate was discontinued and the patient had subsequent gradual improvement in renal function with final serum creatinine of 1.8 mg/dL at 1 month of follow up. Careful monitoring of serum creatinine and awareness of the potential nephrotoxicity may avert the development of acute renal failure in osteoporosis patients treated with this agent." @default.
- W2552290841 created "2016-11-30" @default.
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- W2552290841 date "2016-01-01" @default.
- W2552290841 modified "2023-09-23" @default.
- W2552290841 title "Early onset acute tubular necrosis following single infusion of zoledronate" @default.
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- W2552290841 doi "https://doi.org/10.11138/ccmbm/2016.13.2.154" @default.
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