Matches in SemOpenAlex for { <https://semopenalex.org/work/W2552421957> ?p ?o ?g. }
- W2552421957 endingPage "181" @default.
- W2552421957 startingPage "170" @default.
- W2552421957 abstract "Small intestinal neuroendocrine tumors (SI-NETs) are amine- and peptide-producing neoplasms. Most patients display metastases at the time of diagnosis; they have an unpredictable individual disease course and the tumors are often therapy resistant. Chromogranin A and 5-hydroxyindoleacetic acid are the biomarkers clinically used most often today, but there is a great need for novel diagnostic and prognostic biomarkers and new therapeutic targets. Sixty-nine biomarkers were screened in serum from 23 SI-NET patients and 23 healthy controls using the multiplex proximity ligation assay (PLA). A refined method, the proximity extension assay (PEA), was used to analyze 76 additional biomarkers. Statistical testing and multivariate classification were performed. Immunohistochemistry and ELISA were performed in an extended cohort. Using PLA, 19 biomarkers showed a significant difference in serum concentrations between patients and controls, and PEA revealed a difference in the concentrations of 17 proteins. Multivariate classification analysis revealed decoy receptor 3 (DcR3), trefoil factor 3 (TFF3), and midkine to be good biomarkers for the disease, which was confirmed by ELISA analysis. All 3 biomarkers were expressed in tumor tissue. DcR3 concentrations were elevated in patients with stage IV disease. High concentrations of DcR3 and TFF3 were correlated to poor survival. DcR3, TFF3, and midkine exhibited elevated serum concentrations in SI-NET patients compared to healthy controls, and DcR3 and TFF3 were associated with poor survival. DcR3 seems to be a marker for liver metastases, while TFF3 and midkine may be new diagnostic biomarkers for SI-NETs." @default.
- W2552421957 created "2016-11-30" @default.
- W2552421957 creator A5013712015 @default.
- W2552421957 creator A5024036758 @default.
- W2552421957 creator A5031987659 @default.
- W2552421957 creator A5047715660 @default.
- W2552421957 creator A5057108575 @default.
- W2552421957 creator A5061296710 @default.
- W2552421957 creator A5068301533 @default.
- W2552421957 creator A5076081824 @default.
- W2552421957 date "2016-11-09" @default.
- W2552421957 modified "2023-09-22" @default.
- W2552421957 title "DcR3, TFF3, and Midkine Are Novel Serum Biomarkers in Small Intestinal Neuroendocrine Tumors" @default.
- W2552421957 cites W1499564085 @default.
- W2552421957 cites W1514428065 @default.
- W2552421957 cites W1851391090 @default.
- W2552421957 cites W1902846622 @default.
- W2552421957 cites W1963249638 @default.
- W2552421957 cites W1966626540 @default.
- W2552421957 cites W1971424313 @default.
- W2552421957 cites W1980396580 @default.
- W2552421957 cites W1982269622 @default.
- W2552421957 cites W1982560070 @default.
- W2552421957 cites W1987282558 @default.
- W2552421957 cites W1996401440 @default.
- W2552421957 cites W1998041089 @default.
- W2552421957 cites W2001984393 @default.
- W2552421957 cites W2006303213 @default.
- W2552421957 cites W2010084870 @default.
- W2552421957 cites W2012565620 @default.
- W2552421957 cites W2029287947 @default.
- W2552421957 cites W2036657493 @default.
- W2552421957 cites W2038390061 @default.
- W2552421957 cites W2040887036 @default.
- W2552421957 cites W2049055842 @default.
- W2552421957 cites W2050852925 @default.
- W2552421957 cites W2059265677 @default.
- W2552421957 cites W2060114727 @default.
- W2552421957 cites W2065529053 @default.
- W2552421957 cites W2071253692 @default.
- W2552421957 cites W2074731710 @default.
- W2552421957 cites W2076736672 @default.
- W2552421957 cites W2078525166 @default.
- W2552421957 cites W2096061266 @default.
- W2552421957 cites W2113530405 @default.
- W2552421957 cites W2120810131 @default.
- W2552421957 cites W2123733004 @default.
- W2552421957 cites W2124074488 @default.
- W2552421957 cites W2138273457 @default.
- W2552421957 cites W2149684422 @default.
- W2552421957 cites W2157164206 @default.
- W2552421957 cites W2168636560 @default.
- W2552421957 cites W2169526860 @default.
- W2552421957 cites W2169967154 @default.
- W2552421957 cites W2170333388 @default.
- W2552421957 cites W2171625824 @default.
- W2552421957 cites W273955616 @default.
- W2552421957 cites W286131682 @default.
- W2552421957 cites W2911964244 @default.
- W2552421957 cites W2059493933 @default.
- W2552421957 doi "https://doi.org/10.1159/000452891" @default.
- W2552421957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27829249" @default.
- W2552421957 hasPublicationYear "2016" @default.
- W2552421957 type Work @default.
- W2552421957 sameAs 2552421957 @default.
- W2552421957 citedByCount "20" @default.
- W2552421957 countsByYear W25524219572017 @default.
- W2552421957 countsByYear W25524219572018 @default.
- W2552421957 countsByYear W25524219572019 @default.
- W2552421957 countsByYear W25524219572020 @default.
- W2552421957 countsByYear W25524219572021 @default.
- W2552421957 countsByYear W25524219572022 @default.
- W2552421957 countsByYear W25524219572023 @default.
- W2552421957 crossrefType "journal-article" @default.
- W2552421957 hasAuthorship W2552421957A5013712015 @default.
- W2552421957 hasAuthorship W2552421957A5024036758 @default.
- W2552421957 hasAuthorship W2552421957A5031987659 @default.
- W2552421957 hasAuthorship W2552421957A5047715660 @default.
- W2552421957 hasAuthorship W2552421957A5057108575 @default.
- W2552421957 hasAuthorship W2552421957A5061296710 @default.
- W2552421957 hasAuthorship W2552421957A5068301533 @default.
- W2552421957 hasAuthorship W2552421957A5076081824 @default.
- W2552421957 hasConcept C126322002 @default.
- W2552421957 hasConcept C142724271 @default.
- W2552421957 hasConcept C158074577 @default.
- W2552421957 hasConcept C170493617 @default.
- W2552421957 hasConcept C204232928 @default.
- W2552421957 hasConcept C2775960820 @default.
- W2552421957 hasConcept C2776243700 @default.
- W2552421957 hasConcept C2779066768 @default.
- W2552421957 hasConcept C2779134260 @default.
- W2552421957 hasConcept C2781197716 @default.
- W2552421957 hasConcept C55493867 @default.
- W2552421957 hasConcept C71924100 @default.
- W2552421957 hasConcept C77231918 @default.
- W2552421957 hasConcept C86803240 @default.
- W2552421957 hasConcept C90924648 @default.
- W2552421957 hasConceptScore W2552421957C126322002 @default.