FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2552495511> ?p ?o ?g. }

• W2552495511 endingPage "1848" @default.
• W2552495511 startingPage "1848" @default.
• W2552495511 abstract "The IBTK gene encodes the major protein isoform IBTKα that was recently characterized as substrate receptor of Cul3-dependent E3 ligase, regulating ubiquitination coupled to proteasomal degradation of Pdcd4, an inhibitor of translation. Due to the presence of Ankyrin-BTB-RCC1 domains that mediate several protein-protein interactions, IBTKα could exert expanded regulatory roles, including interaction with transcription regulators. To verify the effects of IBTKα on gene expression, we analyzed HeLa and K562 cell transcriptomes by RNA-Sequencing before and after IBTK knock-down by shRNA transduction. In HeLa cells, 1285 (2.03%) of 63,128 mapped transcripts were differentially expressed in IBTK-shRNA-transduced cells, as compared to cells treated with control-shRNA, with 587 upregulated (45.7%) and 698 downregulated (54.3%) RNAs. In K562 cells, 1959 (3.1%) of 63128 mapped RNAs were differentially expressed in IBTK-shRNA-transduced cells, including 1053 upregulated (53.7%) and 906 downregulated (46.3%). Only 137 transcripts (0.22%) were commonly deregulated by IBTK silencing in both HeLa and K562 cells, indicating that most IBTKα effects on gene expression are cell type-specific. Based on gene ontology classification, the genes responsive to IBTK are involved in different biological processes, including in particular chromatin and nucleosomal organization, gene expression regulation, and cellular traffic and migration. In addition, IBTK RNA interference affected RNA maturation in both cell lines, as shown by the evidence of alternative 3'- and 5'-splicing, mutually exclusive exons, retained introns, and skipped exons. Altogether, these results indicate that IBTK differently modulates gene expression and RNA splicing in HeLa and K562 cells, demonstrating a novel biological role of this protein." @default.
• W2552495511 created "2016-11-30" @default.
• W2552495511 creator A5001102777 @default.
• W2552495511 creator A5002260566 @default.
• W2552495511 creator A5012337000 @default.
• W2552495511 creator A5027905905 @default.
• W2552495511 creator A5028861390 @default.
• W2552495511 creator A5029888246 @default.
• W2552495511 creator A5030152612 @default.
• W2552495511 creator A5030348438 @default.
• W2552495511 creator A5036489838 @default.
• W2552495511 creator A5041571738 @default.
• W2552495511 creator A5044715881 @default.
• W2552495511 creator A5053703215 @default.
• W2552495511 creator A5059266323 @default.
• W2552495511 creator A5061245348 @default.
• W2552495511 creator A5062018914 @default.
• W2552495511 creator A5076810301 @default.
• W2552495511 creator A5077903787 @default.
• W2552495511 creator A5078122346 @default.
• W2552495511 creator A5078128674 @default.
• W2552495511 date "2016-11-07" @default.
• W2552495511 modified "2023-10-13" @default.
• W2552495511 title "IBTK Differently Modulates Gene Expression and RNA Splicing in HeLa and K562 Cells" @default.
• W2552495511 cites W1444458795 @default.
• W2552495511 cites W1535995985 @default.
• W2552495511 cites W159942249 @default.
• W2552495511 cites W1853479735 @default.
• W2552495511 cites W1973921593 @default.
• W2552495511 cites W1995972219 @default.
• W2552495511 cites W2009931781 @default.
• W2552495511 cites W2012264295 @default.
• W2552495511 cites W2020984737 @default.
• W2552495511 cites W2028447166 @default.
• W2552495511 cites W2062387508 @default.
• W2552495511 cites W2065155413 @default.
• W2552495511 cites W2074700519 @default.
• W2552495511 cites W2085257439 @default.
• W2552495511 cites W2089367277 @default.
• W2552495511 cites W2102528998 @default.
• W2552495511 cites W2103823493 @default.
• W2552495511 cites W2126052031 @default.
• W2552495511 cites W2126709672 @default.
• W2552495511 cites W2131324791 @default.
• W2552495511 cites W2131358717 @default.
• W2552495511 cites W2131778155 @default.
• W2552495511 cites W2152239989 @default.
• W2552495511 cites W2152588363 @default.
• W2552495511 cites W2153598858 @default.
• W2552495511 cites W2159956236 @default.
• W2552495511 cites W2166820820 @default.
• W2552495511 cites W2208114687 @default.
• W2552495511 cites W2236822143 @default.
• W2552495511 cites W2328415948 @default.
• W2552495511 cites W2343778820 @default.
• W2552495511 cites W2375849612 @default.
• W2552495511 cites W2418770118 @default.
• W2552495511 doi "https://doi.org/10.3390/ijms17111848" @default.
• W2552495511 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5133848" @default.
• W2552495511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27827994" @default.
• W2552495511 hasPublicationYear "2016" @default.
• W2552495511 type Work @default.
• W2552495511 sameAs 2552495511 @default.
• W2552495511 citedByCount "10" @default.
• W2552495511 countsByYear W25524955112018 @default.
• W2552495511 countsByYear W25524955112019 @default.
• W2552495511 countsByYear W25524955112020 @default.
• W2552495511 countsByYear W25524955112022 @default.
• W2552495511 crossrefType "journal-article" @default.
• W2552495511 hasAuthorship W2552495511A5001102777 @default.
• W2552495511 hasAuthorship W2552495511A5002260566 @default.
• W2552495511 hasAuthorship W2552495511A5012337000 @default.
• W2552495511 hasAuthorship W2552495511A5027905905 @default.
• W2552495511 hasAuthorship W2552495511A5028861390 @default.
• W2552495511 hasAuthorship W2552495511A5029888246 @default.
• W2552495511 hasAuthorship W2552495511A5030152612 @default.
• W2552495511 hasAuthorship W2552495511A5030348438 @default.
• W2552495511 hasAuthorship W2552495511A5036489838 @default.
• W2552495511 hasAuthorship W2552495511A5041571738 @default.
• W2552495511 hasAuthorship W2552495511A5044715881 @default.
• W2552495511 hasAuthorship W2552495511A5053703215 @default.
• W2552495511 hasAuthorship W2552495511A5059266323 @default.
• W2552495511 hasAuthorship W2552495511A5061245348 @default.
• W2552495511 hasAuthorship W2552495511A5062018914 @default.
• W2552495511 hasAuthorship W2552495511A5076810301 @default.
• W2552495511 hasAuthorship W2552495511A5077903787 @default.
• W2552495511 hasAuthorship W2552495511A5078122346 @default.
• W2552495511 hasAuthorship W2552495511A5078128674 @default.
• W2552495511 hasBestOaLocation W25524955111 @default.
• W2552495511 hasConcept C104317684 @default.
• W2552495511 hasConcept C119056186 @default.
• W2552495511 hasConcept C150194340 @default.
• W2552495511 hasConcept C153911025 @default.
• W2552495511 hasConcept C166703698 @default.
• W2552495511 hasConcept C171122931 @default.
• W2552495511 hasConcept C173396325 @default.
• W2552495511 hasConcept C190232843 @default.
• W2552495511 hasConcept C194583182 @default.

• next