FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2552577524> ?p ?o ?g. }

• W2552577524 abstract "Abstract Introduction All symptomatic multiple myeloma (MM) patients are virtually preceded by a precursor disease (PD). However, the PD is rarely known at the time of diagnosis of MM. Several PD can progress to MM: monoclonal gammopathy of undetermined significance (MGUS), smoldering MM (SMM) and solitary plasmacytoma (SP). Sigurdardottir et al have recently demonstrated that only 2.7% in a series of 14798 MM patients had prior knowledge of MGUS. This group had better overall survival (OS), stressing the importance of clinical follow-up in MGUS and suggesting that earlier treatment of MM leads to better OS. Nonetheless, we have recently shown that diagnostic delay in MM have a paradoxical effect on OS. Furthermore, little is known about the outcome of MM with prior knowledge of other PD. Methods All symptomatic MM patients diagnosed between January 1993 and July 2015 in our MM population-based registry, excluding palliative patients, were selected. Information about any prior PD was checked, as well as baseline common prognostic factors such as age, sex, lactate dehydrogenase (LDH), creatinine (Cr), International Staging System (ISS), high-risk FISH, and diagnostic delay. Comparisons among groups were made with the χ2-testfor categorical and t-test for quantitative variables. OS was estimated in months (m) by the Kaplan-Meier method in patients with or without specific PD or any PD as a whole. Log-rank test was used to compare curves. A Cox proportional hazard model was used to assess the simultaneous impact on survival of prior PD and other predictors. Results 473 MM patients fulfilled the inclusion criteria. 383 of them (81%) had available data concerning prior PD. There were 233 men and 240 women (50.7%), median age 67 years (12-87). 19 patients (5%), 10 (2.6%) and 5 (1.3%) had prior MGUS, SP and SMM, respectively. The group without prior PD had significantly higher values of serum Cr (2.09 vs 1.09 mg/dL, p<0.001), LDH (317.3 vs 256.2 U/L, p=0.09), ISS3 (49.6% vs 22.2, p=0.02), but less delay (5.6 vs 10.9 m, p=0.002). Median OS of patients with prior MGUS was 87.7 m (57.1-118.2) vs 34.4 (27.8-41.1)(p=0.112), with prior SP 88 m (46.9-129) vs 34.9 (28.4-41.5)(p=0.101) and prior SMM 104.1 m vs 36 (29.9-42.1)(p=0.102). Median OS of any PD (Fig 1) was 88 m (82.6-93.3) vs 32.7 (26.2-39.2)(p=0.006). In the multivariate model, age, LDH and Cr are significantly associated with survival. The presence of prior PD, when adjusting for these factors, is also significantly associated with survival, acting as a protective factor. When ISS is added to the model, prior PD remains only marginally significant. Conclusion Prior knowledge of PD is infrequent at the moment of MM diagnosis. MM with any previously documented PD seems to have better outcome. The reason for this finding is not an earlier diagnosis, but rather a better prognostic profile. However, we cannot rule out other underlying biological mechanisms. More and larger studies are warranted to confirm our results. Disclosures No relevant conflicts of interest to declare." @default.
• W2552577524 created "2016-11-30" @default.
• W2552577524 creator A5000307833 @default.
• W2552577524 creator A5002845944 @default.
• W2552577524 creator A5012564353 @default.
• W2552577524 creator A5018334882 @default.
• W2552577524 creator A5035200286 @default.
• W2552577524 creator A5039394425 @default.
• W2552577524 creator A5042858914 @default.
• W2552577524 creator A5046576670 @default.
• W2552577524 creator A5049205706 @default.
• W2552577524 creator A5054342923 @default.
• W2552577524 creator A5072166341 @default.
• W2552577524 creator A5083811092 @default.
• W2552577524 date "2015-12-03" @default.
• W2552577524 modified "2023-10-17" @default.
• W2552577524 title "Multiple Myeloma with Prior Precursor Disease Shows Better Outcome" @default.
• W2552577524 doi "https://doi.org/10.1182/blood.v126.23.1756.1756" @default.
• W2552577524 hasPublicationYear "2015" @default.
• W2552577524 type Work @default.
• W2552577524 sameAs 2552577524 @default.
• W2552577524 citedByCount "1" @default.
• W2552577524 countsByYear W25525775242019 @default.
• W2552577524 crossrefType "journal-article" @default.
• W2552577524 hasAuthorship W2552577524A5000307833 @default.
• W2552577524 hasAuthorship W2552577524A5002845944 @default.
• W2552577524 hasAuthorship W2552577524A5012564353 @default.
• W2552577524 hasAuthorship W2552577524A5018334882 @default.
• W2552577524 hasAuthorship W2552577524A5035200286 @default.
• W2552577524 hasAuthorship W2552577524A5039394425 @default.
• W2552577524 hasAuthorship W2552577524A5042858914 @default.
• W2552577524 hasAuthorship W2552577524A5046576670 @default.
• W2552577524 hasAuthorship W2552577524A5049205706 @default.
• W2552577524 hasAuthorship W2552577524A5054342923 @default.
• W2552577524 hasAuthorship W2552577524A5072166341 @default.
• W2552577524 hasAuthorship W2552577524A5083811092 @default.
• W2552577524 hasConcept C126322002 @default.
• W2552577524 hasConcept C141071460 @default.
• W2552577524 hasConcept C143998085 @default.
• W2552577524 hasConcept C159654299 @default.
• W2552577524 hasConcept C163864487 @default.
• W2552577524 hasConcept C191093355 @default.
• W2552577524 hasConcept C203014093 @default.
• W2552577524 hasConcept C207103383 @default.
• W2552577524 hasConcept C2776364478 @default.
• W2552577524 hasConcept C2777250017 @default.
• W2552577524 hasConcept C2908647359 @default.
• W2552577524 hasConcept C44249647 @default.
• W2552577524 hasConcept C50382708 @default.
• W2552577524 hasConcept C542903549 @default.
• W2552577524 hasConcept C66339696 @default.
• W2552577524 hasConcept C71924100 @default.
• W2552577524 hasConcept C90924648 @default.
• W2552577524 hasConcept C99454951 @default.
• W2552577524 hasConceptScore W2552577524C126322002 @default.
• W2552577524 hasConceptScore W2552577524C141071460 @default.
• W2552577524 hasConceptScore W2552577524C143998085 @default.
• W2552577524 hasConceptScore W2552577524C159654299 @default.
• W2552577524 hasConceptScore W2552577524C163864487 @default.
• W2552577524 hasConceptScore W2552577524C191093355 @default.
• W2552577524 hasConceptScore W2552577524C203014093 @default.
• W2552577524 hasConceptScore W2552577524C207103383 @default.
• W2552577524 hasConceptScore W2552577524C2776364478 @default.
• W2552577524 hasConceptScore W2552577524C2777250017 @default.
• W2552577524 hasConceptScore W2552577524C2908647359 @default.
• W2552577524 hasConceptScore W2552577524C44249647 @default.
• W2552577524 hasConceptScore W2552577524C50382708 @default.
• W2552577524 hasConceptScore W2552577524C542903549 @default.
• W2552577524 hasConceptScore W2552577524C66339696 @default.
• W2552577524 hasConceptScore W2552577524C71924100 @default.
• W2552577524 hasConceptScore W2552577524C90924648 @default.
• W2552577524 hasConceptScore W2552577524C99454951 @default.
• W2552577524 hasLocation W25525775241 @default.
• W2552577524 hasOpenAccess W2552577524 @default.
• W2552577524 hasPrimaryLocation W25525775241 @default.
• W2552577524 hasRelatedWork W2012454018 @default.
• W2552577524 hasRelatedWork W2043427586 @default.
• W2552577524 hasRelatedWork W2065354970 @default.
• W2552577524 hasRelatedWork W2065751921 @default.
• W2552577524 hasRelatedWork W2094843774 @default.
• W2552577524 hasRelatedWork W2229743977 @default.
• W2552577524 hasRelatedWork W2295848845 @default.
• W2552577524 hasRelatedWork W2472518751 @default.
• W2552577524 hasRelatedWork W2496116834 @default.
• W2552577524 hasRelatedWork W2509297406 @default.
• W2552577524 hasRelatedWork W2526272943 @default.
• W2552577524 hasRelatedWork W2536676925 @default.
• W2552577524 hasRelatedWork W2550118828 @default.
• W2552577524 hasRelatedWork W2583252802 @default.
• W2552577524 hasRelatedWork W2586612458 @default.
• W2552577524 hasRelatedWork W2587207493 @default.
• W2552577524 hasRelatedWork W2744374394 @default.
• W2552577524 hasRelatedWork W2904887089 @default.
• W2552577524 hasRelatedWork W2912698799 @default.
• W2552577524 hasRelatedWork W2985071330 @default.
• W2552577524 isParatext "false" @default.
• W2552577524 isRetracted "false" @default.
• W2552577524 magId "2552577524" @default.
• W2552577524 workType "article" @default.