FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2552593178> ?p ?o ?g. }

• W2552593178 endingPage "24" @default.
• W2552593178 startingPage "16" @default.
• W2552593178 abstract "Hsp90 inhibitors have been investigated as cancer therapeutics in monotherapy and to augment radiotherapy; however, serious adverse effects of early-generation Hsp90 inhibitors limited their development. TAS-116 is a novel Hsp90 inhibitor with lower adverse effects than other Hsp90 inhibitors, and here, we investigated the radiosensitizing effects of TAS-116 in low linear energy transfer (LET) X-ray and high LET carbon ion-irradiated human cancer cells and mouse tumor xenografts. TAS-116 decreased cell survival of both X-ray and carbon ion-irradiated human cancer cell lines (HeLa and H1299 cells), and similar to other Hsp90 inhibitors, it did not affect radiosensitivity of noncancerous human fibroblasts. TAS-116 increased the number of radiation-induced γ-H2AX foci and delayed the repair of DNA double-strand breaks (DSB). TAS-116 reduced the expression of proteins that mediate repair of DSBs by homologous recombination (RAD51) and nonhomologous end joining (Ku, DNA-PKcs), and suppressed formation of RAD51 foci and phosphorylation/activation of DNA-PKcs. TAS-116 also decreased expression of the cdc25 cell-cycle progression marker, markedly increasing G2-M arrest. Combined treatment of mouse tumor xenografts with carbon ions and TAS-116 showed promising delay in tumor growth compared with either individual treatment. These results demonstrate that TAS-116 radiosensitizes human cancer cells to both X-rays and carbon ions by inhibiting the two major DSB repair pathways, and these effects were accompanied by marked cell-cycle arrest. The promising results of combination TAS-116 + carbon ion radiotherapy of tumor xenografts justify further exploration of TAS-116 as an adjunct to radiotherapy using low or high LET radiation. Mol Cancer Ther; 16(1); 16-24. ©2016 AACR." @default.
• W2552593178 created "2016-11-30" @default.
• W2552593178 creator A5008712114 @default.
• W2552593178 creator A5036598584 @default.
• W2552593178 creator A5054332041 @default.
• W2552593178 creator A5074581569 @default.
• W2552593178 creator A5086443802 @default.
• W2552593178 creator A5089334540 @default.
• W2552593178 date "2017-01-01" @default.
• W2552593178 modified "2023-10-14" @default.
• W2552593178 title "TAS-116, a Novel Hsp90 Inhibitor, Selectively Enhances Radiosensitivity of Human Cancer Cells to X-rays and Carbon Ion Radiation" @default.
• W2552593178 cites W1861243942 @default.
• W2552593178 cites W1967251446 @default.
• W2552593178 cites W1967455939 @default.
• W2552593178 cites W1970693402 @default.
• W2552593178 cites W1971288669 @default.
• W2552593178 cites W1978356732 @default.
• W2552593178 cites W1988675578 @default.
• W2552593178 cites W1998959684 @default.
• W2552593178 cites W1999346813 @default.
• W2552593178 cites W1999763581 @default.
• W2552593178 cites W2000929246 @default.
• W2552593178 cites W2002044132 @default.
• W2552593178 cites W2004167207 @default.
• W2552593178 cites W2012172048 @default.
• W2552593178 cites W2013895149 @default.
• W2552593178 cites W2021970375 @default.
• W2552593178 cites W2022529631 @default.
• W2552593178 cites W2023824514 @default.
• W2552593178 cites W2024234954 @default.
• W2552593178 cites W2029431941 @default.
• W2552593178 cites W2032109769 @default.
• W2552593178 cites W2036225927 @default.
• W2552593178 cites W2055725338 @default.
• W2552593178 cites W2057574712 @default.
• W2552593178 cites W2059730232 @default.
• W2552593178 cites W2074868019 @default.
• W2552593178 cites W2092255361 @default.
• W2552593178 cites W2098070947 @default.
• W2552593178 cites W2100214216 @default.
• W2552593178 cites W2100598040 @default.
• W2552593178 cites W2109945789 @default.
• W2552593178 cites W2117986099 @default.
• W2552593178 cites W2130986759 @default.
• W2552593178 cites W2134565827 @default.
• W2552593178 cites W2137640850 @default.
• W2552593178 cites W2154745425 @default.
• W2552593178 cites W2165563508 @default.
• W2552593178 cites W2166284889 @default.
• W2552593178 cites W2167356883 @default.
• W2552593178 cites W2193491018 @default.
• W2552593178 doi "https://doi.org/10.1158/1535-7163.mct-16-0573" @default.
• W2552593178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5221699" @default.
• W2552593178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28062703" @default.
• W2552593178 hasPublicationYear "2017" @default.
• W2552593178 type Work @default.
• W2552593178 sameAs 2552593178 @default.
• W2552593178 citedByCount "22" @default.
• W2552593178 countsByYear W25525931782017 @default.
• W2552593178 countsByYear W25525931782018 @default.
• W2552593178 countsByYear W25525931782019 @default.
• W2552593178 countsByYear W25525931782020 @default.
• W2552593178 countsByYear W25525931782021 @default.
• W2552593178 countsByYear W25525931782022 @default.
• W2552593178 countsByYear W25525931782023 @default.
• W2552593178 crossrefType "journal-article" @default.
• W2552593178 hasAuthorship W2552593178A5008712114 @default.
• W2552593178 hasAuthorship W2552593178A5036598584 @default.
• W2552593178 hasAuthorship W2552593178A5054332041 @default.
• W2552593178 hasAuthorship W2552593178A5074581569 @default.
• W2552593178 hasAuthorship W2552593178A5086443802 @default.
• W2552593178 hasAuthorship W2552593178A5089334540 @default.
• W2552593178 hasBestOaLocation W25525931781 @default.
• W2552593178 hasConcept C102744134 @default.
• W2552593178 hasConcept C104317684 @default.
• W2552593178 hasConcept C105696609 @default.
• W2552593178 hasConcept C121608353 @default.
• W2552593178 hasConcept C122917832 @default.
• W2552593178 hasConcept C126322002 @default.
• W2552593178 hasConcept C134935766 @default.
• W2552593178 hasConcept C143425029 @default.
• W2552593178 hasConcept C1491633281 @default.
• W2552593178 hasConcept C153911025 @default.
• W2552593178 hasConcept C185592680 @default.
• W2552593178 hasConcept C205260736 @default.
• W2552593178 hasConcept C206684579 @default.
• W2552593178 hasConcept C2775932338 @default.
• W2552593178 hasConcept C2777366897 @default.
• W2552593178 hasConcept C2777560012 @default.
• W2552593178 hasConcept C2779012473 @default.
• W2552593178 hasConcept C2910615947 @default.
• W2552593178 hasConcept C29537977 @default.
• W2552593178 hasConcept C502942594 @default.
• W2552593178 hasConcept C509974204 @default.
• W2552593178 hasConcept C54355233 @default.
• W2552593178 hasConcept C552990157 @default.
• W2552593178 hasConcept C55493867 @default.
• W2552593178 hasConcept C71924100 @default.

• next