Matches in SemOpenAlex for { <https://semopenalex.org/work/W2552605659> ?p ?o ?g. }
- W2552605659 endingPage "1516" @default.
- W2552605659 startingPage "1516" @default.
- W2552605659 abstract "Identification of active compounds from natural products is a critical and challenging task in drug discovery pipelines. Besides commonly used bio-guided screening approaches, affinity selection strategy coupled with liquid chromatography or mass spectrometry, known as ligand fishing, has been gaining increasing interest from researchers. In this review, we summarized this emerging strategy and categorized those methods as off-line or on-line mode according to their features. The separation principles of ligand fishing were introduced based on distinct analytical techniques, including biochromatography, capillary electrophoresis, ultrafiltration, equilibrium dialysis, microdialysis, and magnetic beads. The applications of ligand fishing approaches in the discovery of lead compounds were reviewed. Most of ligand fishing methods display specificity, high efficiency, and require less sample pretreatment, which makes them especially suitable for screening active compounds from complex mixtures of natural products. We also summarized the applications of ligand fishing in the modernization of Traditional Chinese Medicine (TCM), and propose some perspectives of this remarkable technique." @default.
- W2552605659 created "2016-11-30" @default.
- W2552605659 creator A5015732550 @default.
- W2552605659 creator A5075241169 @default.
- W2552605659 creator A5088664989 @default.
- W2552605659 creator A5091163594 @default.
- W2552605659 date "2016-11-11" @default.
- W2552605659 modified "2023-10-18" @default.
- W2552605659 title "Ligand Fishing: A Remarkable Strategy for Discovering Bioactive Compounds from Complex Mixture of Natural Products" @default.
- W2552605659 cites W1481549938 @default.
- W2552605659 cites W1504856640 @default.
- W2552605659 cites W1770949911 @default.
- W2552605659 cites W1868334373 @default.
- W2552605659 cites W1880550110 @default.
- W2552605659 cites W1964700258 @default.
- W2552605659 cites W1965003536 @default.
- W2552605659 cites W1965627867 @default.
- W2552605659 cites W1966212997 @default.
- W2552605659 cites W1968306744 @default.
- W2552605659 cites W1970715422 @default.
- W2552605659 cites W1971209239 @default.
- W2552605659 cites W1973348005 @default.
- W2552605659 cites W1976379237 @default.
- W2552605659 cites W1978634070 @default.
- W2552605659 cites W1979055232 @default.
- W2552605659 cites W1983799392 @default.
- W2552605659 cites W1984364596 @default.
- W2552605659 cites W1986612337 @default.
- W2552605659 cites W1992356181 @default.
- W2552605659 cites W1994542794 @default.
- W2552605659 cites W1996506120 @default.
- W2552605659 cites W1999229873 @default.
- W2552605659 cites W1999547512 @default.
- W2552605659 cites W2013156148 @default.
- W2552605659 cites W2016029365 @default.
- W2552605659 cites W2021764882 @default.
- W2552605659 cites W2024211702 @default.
- W2552605659 cites W2024680546 @default.
- W2552605659 cites W2028362517 @default.
- W2552605659 cites W2032644318 @default.
- W2552605659 cites W2033346504 @default.
- W2552605659 cites W2040602650 @default.
- W2552605659 cites W2043026524 @default.
- W2552605659 cites W2046258284 @default.
- W2552605659 cites W2047868083 @default.
- W2552605659 cites W2050773357 @default.
- W2552605659 cites W2050859052 @default.
- W2552605659 cites W2053360005 @default.
- W2552605659 cites W2057330781 @default.
- W2552605659 cites W2057696613 @default.
- W2552605659 cites W2059809566 @default.
- W2552605659 cites W2060613990 @default.
- W2552605659 cites W2062219625 @default.
- W2552605659 cites W2063688418 @default.
- W2552605659 cites W2067664537 @default.
- W2552605659 cites W2068878205 @default.
- W2552605659 cites W2071810654 @default.
- W2552605659 cites W2079976145 @default.
- W2552605659 cites W2081575332 @default.
- W2552605659 cites W2084123824 @default.
- W2552605659 cites W2084191509 @default.
- W2552605659 cites W2087510984 @default.
- W2552605659 cites W2089961278 @default.
- W2552605659 cites W2098873635 @default.
- W2552605659 cites W2105005778 @default.
- W2552605659 cites W2146426144 @default.
- W2552605659 cites W2149777060 @default.
- W2552605659 cites W2154347237 @default.
- W2552605659 cites W2161390898 @default.
- W2552605659 cites W2217819442 @default.
- W2552605659 cites W2237691230 @default.
- W2552605659 cites W2266542026 @default.
- W2552605659 cites W2271356644 @default.
- W2552605659 cites W2327534799 @default.
- W2552605659 cites W2328008431 @default.
- W2552605659 cites W2330245937 @default.
- W2552605659 cites W2334966290 @default.
- W2552605659 cites W2402253588 @default.
- W2552605659 cites W2406301238 @default.
- W2552605659 cites W261407987 @default.
- W2552605659 doi "https://doi.org/10.3390/molecules21111516" @default.
- W2552605659 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6274472" @default.
- W2552605659 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27845727" @default.
- W2552605659 hasPublicationYear "2016" @default.
- W2552605659 type Work @default.
- W2552605659 sameAs 2552605659 @default.
- W2552605659 citedByCount "70" @default.
- W2552605659 countsByYear W25526056592017 @default.
- W2552605659 countsByYear W25526056592018 @default.
- W2552605659 countsByYear W25526056592019 @default.
- W2552605659 countsByYear W25526056592020 @default.
- W2552605659 countsByYear W25526056592021 @default.
- W2552605659 countsByYear W25526056592022 @default.
- W2552605659 countsByYear W25526056592023 @default.
- W2552605659 crossrefType "journal-article" @default.
- W2552605659 hasAuthorship W2552605659A5015732550 @default.
- W2552605659 hasAuthorship W2552605659A5075241169 @default.
- W2552605659 hasAuthorship W2552605659A5088664989 @default.