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- W2552672273 abstract "The aim of this study was to develop a method for discriminating between patients with Alzheimer disease (AD) and healthy subjects using layer analysis of cerebral blood flow (CBF) and xenon solubility coefficient (λ) in xenon-enhanced computed tomography (CT).Xenon-enhanced CT was performed on 27 patients with AD (81.7 [3.3] years old) and 15 healthy volunteers (78.6 [4.0] years old) using a wide volume CT. For each subject, we created the first- (surface) to sixth-layer images of CBF and λ for the 6 viewing directions (layer thickness, 5 mm). For the discriminant views, receiver operating characteristic curves for the ratio of CBF to λ were created to identify patients with AD.For the third- and fourth-layer left lateral views, which were designated as the discriminant views, areas under the receiver operating characteristic curve were 96.8% and 97.4%, respectively.With the use of the discriminant views obtained by xenon-enhanced CT, we could effectively discriminate between patients with AD and healthy subjects using both CBF and λ." @default.
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- W2552672273 date "2017-01-01" @default.
- W2552672273 modified "2023-09-25" @default.
- W2552672273 title "Discrimination Between Patients With Alzheimer Disease and Healthy Subjects Using Layer Analysis of Cerebral Blood Flow and Xenon Solubility Coefficient in Xenon-Enhanced Computed Tomography" @default.
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- W2552672273 doi "https://doi.org/10.1097/rct.0000000000000525" @default.
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