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- W2552674098 abstract "Background: Legionella pneumophila ( L. pneumophila ) is a causative agent of severe pneumonia. Infection leads to a broad host cell response, as evident e.g. on the transcriptional level. Chromatin modifications, which control gene expression, play a central role in the transcriptional response to L. pneumophila . We set out to find key factors of the host´s response to L. pneumophila by looking at prominent chromatin modifications upon infection. Methods: We infected human blood-derived macrophages with L. pneumophila and used chromatin immunoprecipitation followed by sequencing (ChIP-Seq) to screen for gene promoters with the activating histone 4 acetylation mark (pan-acH4). Results: We found the promoter of tumor necrosis factor, alpha-induced protein 2 (TNFAIP2) to be acetylated at histone H4. This factor has not been characterized in the pathology of L. pneumophila . TNFAIP2 mRNA and protein were upregulated in response to L. pneumophila infection of human blood-derived macrophages and human alveolar epithelial cells (A549). We show that L. pneumophila -induced TNFAIP2 expression is dependent on NF-κB. Importantly, a knockdown of TNFAIP2 led to reduced intracellular replication of L. pneumophila Corby in A549 cells and regulation of several genes. Conclusion: Taken together, genome-wide chromatin analysis of L. pneumophila -infected macrophages demonstrated induction of TNFAIP2, a NF-κB-dependent factor relevant for bacterial replication and host gene expression." @default.
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- W2552674098 date "2016-09-01" @default.
- W2552674098 modified "2023-09-27" @default.
- W2552674098 title "Genome-wide chromatin profiling oflegionella pneumophila-infected human macrophages reveals activation of the pro-bacterial host factor TNFAIP2" @default.
- W2552674098 doi "https://doi.org/10.1183/13993003.congress-2016.pa3969" @default.
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