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• W2552683784 abstract "<b>Background and study aim</b> Upper endoscopy is the most common method for the diagnosis of upper gastrointestinal tract diseases. The aim of this study was to determine whether premedication with simethicone or <i>N</i>-acetylcysteine improves mucosal visualization during upper endoscopy. <b>Patients and methods</b> This was a randomized, double-blind, placebo-controlled study of 297 patients scheduled for upper endoscopy who were premedicated 15 – 30 minutes before the procedure with: 100 mL of water (placebo, group A); water plus 100 mg simethicone (group B); water plus 100 mg simethicone plus 600 mg <i>N</i>-acetylcysteine (group C). The primary outcome measure was the quality of mucosal visualization (score: excellent, adequate or inadequate). <b>Results</b> The addition of simethicone (group B) or simethicone plus <i>N</i>-acetylcysteine to the water (group C) improved the visualization scores of endoscopies compared with water alone (group A). In particular, groups B and C produced a significantly higher percentage of endoscopies with excellent visualization for the esophagus (91.1 % and 86.7 %, respectively, vs. 71.4 % in group A; <i>P</i> < 0.001) and stomach (76.2 % and 74.5 % vs. 38.8 % in group A; <i>P</i> < 0.001). For the duodenum, the use of simethicone also showed an increase in the endoscopies with excellent visualization compared with water alone (85.1 % vs. 73.5 %; <i>P</i> = 0.042). There were no significant differences in scores between groups B and C or between gastric scores in patients with previous subtotal gastrectomy (B and C vs. A): 60.0 % and 42.1 % vs. 28.6 % (<i>P</i> = 0.14). The rate of reported lesions was higher in group B but without statistical significance. <b>Conclusions</b> Premedication with simethicone resulted in better mucosal visibility. Such premedication might improve diagnostic yield, and should be considered for standard practice. Trial registered at ClinicalTrials.gov (NCT02357303)." @default.
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• W2552683784 date "2016-11-16" @default.
• W2552683784 modified "2023-10-18" @default.
• W2552683784 title "Premedication with simethicone and N-acetylcysteine in improving visibility during upper endoscopy: a double-blind randomized trial" @default.
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• W2552683784 doi "https://doi.org/10.1055/s-0042-119034" @default.
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