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- W2552767261 abstract "Psoriasis is a chronic in∞ammatory hu- man skin disorder characterized by T-cell mediated hyperproliferation of Keratinocytes. The exact na- ture of the triggering agent of psoriasis is not yet known. Cell biological flndings on the disease re- vealed that Helper T-cells in the human blood as well as Dendritic Cells play an important role in in∞ict- ing the disease. Further, clinical research suggests that excessive generation of nitric oxide, through a complex chain of bio-chemical events, is causal to the scaliness of psoriatic plaques on human skin. We pro- pose a mathematical model involving the densities of immune cells and Keratinocytes where proliferation of Keratinocytes together with excessive nitric oxide production is precursor to the psoriatic lesions. The model is studied both analytically and numerically. Results are observed to be consistent with the cell biological and clinical flndings." @default.
- W2552767261 created "2016-11-30" @default.
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- W2552767261 date "2010-01-01" @default.
- W2552767261 modified "2023-09-27" @default.
- W2552767261 title "Mathematical Modeling on Immunopathogenesis in Chronic Plaque of Psoriasis: A Theoretical Study" @default.
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