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- W2552786578 abstract "Publisher Summary This chapter presents a study on brain receptors for neurotransmitters. The remarkable growth of this field has been inspired by the promise of success in the development of highly specific pharmacologic agents and in the understanding of synaptic transmission at the molecular level. These studies employed detergent solubilization, as well as organic solvent extraction and Sephadex LH-20 chromatography, for the demonstration of a receptive site which bound [1 4C]dimethyl-rf-tubocurarine with a dissociation constant (K d ) ∼ 10 - 6 M . Of particular importance was their observation that 0. 1 % Triton, which solubilized the majority of the presynaptic membrane, but left junctional complexes intact, did not alter the capacity of the remaining embrane to bind cholinergic ligands. The classic criteria for the identification of postsynaptic receptive sites from the peripheral nervous tissue, that is, ligand binding, has proved inadequate to unambiguously identify equivalent sites from the CNS. Viable alternatives for the assignation of a physiological role to various receptive species may result from the alteration of discrete synaptic processes via developmental, hormonal, and/or surgical manipulation. Such procedures may allow the correlation of ligand binding with physiological response, the ultimate criteria for receptor identification." @default.
- W2552786578 created "2016-11-30" @default.
- W2552786578 creator A5014426396 @default.
- W2552786578 creator A5038633139 @default.
- W2552786578 date "1978-01-01" @default.
- W2552786578 modified "2023-09-24" @default.
- W2552786578 title "Brain Receptors for Neurotransmitters" @default.
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