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- W2552806728 endingPage "2070" @default.
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- W2552806728 abstract "The adverse outcome pathway (AOP) framework provides an alternative to traditional in vivo experiments for the risk assessment of chemicals. AOPs consist of a number of key events (KEs) linked by key event relationships across a range of biological organization backed by scientific evidence. The first KE in the pathway is the molecular initiating event (MIE)—the initial chemical trigger that starts an AOP. Over the past 3 years the AOP conceptual framework has gained a large amount of momentum in toxicology as an alternative to animal methods, and so the MIE has come into the spotlight. What is an MIE? How can MIEs be measured or predicted? What research is currently contributing to our understanding of MIEs? In this Perspective we outline answers to these key questions." @default.
- W2552806728 created "2016-11-30" @default.
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- W2552806728 date "2016-11-30" @default.
- W2552806728 modified "2023-10-16" @default.
- W2552806728 title "A History of the Molecular Initiating Event" @default.
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- W2552806728 doi "https://doi.org/10.1021/acs.chemrestox.6b00341" @default.
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