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• W2552880329 abstract "In our previous work we demonstrated for the first time, to the best of our knowledge, the experimental capability of resonant nanopillars (R-NP) arrays as biochemical transducers. In this Letter, we provide evidence of the capability and suitability of R-NP arrays on a chip to function as label-free optical multiplexed biosensors. R-NP are based on Si3N4/SiO2 Bragg reflectors with a cavity of SiO2. In order to demonstrate the biosensing performance, R-NP were biofunctionalized by the immobilization of IgG antibodies acting as a bioreceptor. This immobilization was carried out through the silanization of the pillars sensing surface with APTMS (3-aminopropyltrimethoxysilane). R-NP were integrated in eight different sensing arrays on a quartz surface chip. An optical fiber bundle monitored each sensing array vertically and independently after each biofunctionalization step, and subsequently after every recognition event of increasing concentrations of anti-IgGs. The results report a novel multiplexed optical biosensor made of eight sensing arrays on a chip with promising performance and yield." @default.
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• W2552880329 date "2016-11-16" @default.
• W2552880329 modified "2023-10-18" @default.
• W2552880329 title "Resonant nanopillars arrays for label-free biosensing" @default.
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• W2552880329 doi "https://doi.org/10.1364/ol.41.005430" @default.
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