Matches in SemOpenAlex for { <https://semopenalex.org/work/W2552931049> ?p ?o ?g. }
- W2552931049 endingPage "1515" @default.
- W2552931049 startingPage "1515" @default.
- W2552931049 abstract "Rooibos extract, due to its glucose and lipid lowering effects, has potential as a nutraceutical for improvement of metabolic dysfunction. Potential herb-drug interactions as a result of the use of natural products are of increasing concern. Cytochrome P450 enzymes, CYP2C8, CYP2C9, and CYP3A4, are important in the metabolism of hypoglycemic drugs, such as thiazolidinediones (TZDs) and sulfonylureas, and hypocholesterolemic drugs, such as atorvastatin. This study investigated the effects of rooibos extracts, prepared from unfermented and fermented rooibos plant material and two of the major bioactive compounds, Z-2-(β-d-glucopyranosyloxy)-3-phenylpropenoic acid (PPAG) and aspalathin (ASP), on Vivid® recombinant CYP450 enzymes. Unfermented (GRT) and fermented (FRE) rooibos extracts inhibited the activity of CYP2C8 (7.69 ± 8.85 µg/mL and 8.93 ± 8.88 µg/mL, respectively) and CYP3A4 (31.33 ± 4.69 µg/mL and 51.44 ± 4.31 µg/mL, respectively) based on their respective IC50 concentrations. Both extracts dose- and time-dependently inhibited CYP2C8 activity, but only time-dependently inhibited CYP2C9. CYP3A4 showed concentration-dependent inhibition by ASP, GRT, and FRE at 25, 50, and 100 µg/mL concentrations. ASP, GRT, and FRE time-dependently inhibited CYP3A4 activity with GRT and FRE showing a more potent time-dependent inhibition, comparable to erythromycin. These findings suggest that herb-drug interactions may occur when nutraceuticals containing rooibos extracts are co-administered with hypoglycemic drugs such as TZDs, sulfonylureas, and dyslipidemic drug, atorvastatin." @default.
- W2552931049 created "2016-11-30" @default.
- W2552931049 creator A5006611112 @default.
- W2552931049 creator A5014988741 @default.
- W2552931049 creator A5020393391 @default.
- W2552931049 creator A5046963541 @default.
- W2552931049 creator A5054856442 @default.
- W2552931049 creator A5058578660 @default.
- W2552931049 date "2016-11-12" @default.
- W2552931049 modified "2023-09-23" @default.
- W2552931049 title "Inhibitory Interactions of Aspalathus linearis (Rooibos) Extracts and Compounds, Aspalathin and Z-2-(β-d-Glucopyranosyloxy)-3-phenylpropenoic Acid, on Cytochromes Metabolizing Hypoglycemic and Hypolipidemic Drugs" @default.
- W2552931049 cites W1484007224 @default.
- W2552931049 cites W1489237918 @default.
- W2552931049 cites W1516528260 @default.
- W2552931049 cites W157413753 @default.
- W2552931049 cites W1971903516 @default.
- W2552931049 cites W1972091423 @default.
- W2552931049 cites W1977262727 @default.
- W2552931049 cites W1978743404 @default.
- W2552931049 cites W1980909867 @default.
- W2552931049 cites W1988689918 @default.
- W2552931049 cites W1990055580 @default.
- W2552931049 cites W1994214890 @default.
- W2552931049 cites W1996009169 @default.
- W2552931049 cites W1996200878 @default.
- W2552931049 cites W1997000370 @default.
- W2552931049 cites W2000364773 @default.
- W2552931049 cites W2001196811 @default.
- W2552931049 cites W2001405761 @default.
- W2552931049 cites W2004142876 @default.
- W2552931049 cites W2004281677 @default.
- W2552931049 cites W2009313893 @default.
- W2552931049 cites W2009952114 @default.
- W2552931049 cites W2015642559 @default.
- W2552931049 cites W2020267609 @default.
- W2552931049 cites W2024024805 @default.
- W2552931049 cites W2025060475 @default.
- W2552931049 cites W2030018298 @default.
- W2552931049 cites W2032659518 @default.
- W2552931049 cites W2033493930 @default.
- W2552931049 cites W2045362322 @default.
- W2552931049 cites W2054410567 @default.
- W2552931049 cites W2062968305 @default.
- W2552931049 cites W2075447600 @default.
- W2552931049 cites W2087725768 @default.
- W2552931049 cites W2088347184 @default.
- W2552931049 cites W2104487496 @default.
- W2552931049 cites W2108405006 @default.
- W2552931049 cites W2112541812 @default.
- W2552931049 cites W2114042463 @default.
- W2552931049 cites W2114160990 @default.
- W2552931049 cites W2122692346 @default.
- W2552931049 cites W2136647292 @default.
- W2552931049 cites W2137940993 @default.
- W2552931049 cites W2139800002 @default.
- W2552931049 cites W2141641231 @default.
- W2552931049 cites W2143014525 @default.
- W2552931049 cites W2146152540 @default.
- W2552931049 cites W2151268696 @default.
- W2552931049 cites W2151554458 @default.
- W2552931049 cites W2152392393 @default.
- W2552931049 cites W2153298837 @default.
- W2552931049 cites W2158345238 @default.
- W2552931049 cites W2168047024 @default.
- W2552931049 cites W2171233986 @default.
- W2552931049 cites W2238800297 @default.
- W2552931049 cites W2394543848 @default.
- W2552931049 cites W2399165565 @default.
- W2552931049 cites W2432810119 @default.
- W2552931049 cites W2471197645 @default.
- W2552931049 cites W2917610618 @default.
- W2552931049 cites W86039894 @default.
- W2552931049 doi "https://doi.org/10.3390/molecules21111515" @default.
- W2552931049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6273468" @default.
- W2552931049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27845750" @default.
- W2552931049 hasPublicationYear "2016" @default.
- W2552931049 type Work @default.
- W2552931049 sameAs 2552931049 @default.
- W2552931049 citedByCount "31" @default.
- W2552931049 countsByYear W25529310492017 @default.
- W2552931049 countsByYear W25529310492018 @default.
- W2552931049 countsByYear W25529310492019 @default.
- W2552931049 countsByYear W25529310492020 @default.
- W2552931049 countsByYear W25529310492021 @default.
- W2552931049 countsByYear W25529310492022 @default.
- W2552931049 crossrefType "journal-article" @default.
- W2552931049 hasAuthorship W2552931049A5006611112 @default.
- W2552931049 hasAuthorship W2552931049A5014988741 @default.
- W2552931049 hasAuthorship W2552931049A5020393391 @default.
- W2552931049 hasAuthorship W2552931049A5046963541 @default.
- W2552931049 hasAuthorship W2552931049A5054856442 @default.
- W2552931049 hasAuthorship W2552931049A5058578660 @default.
- W2552931049 hasBestOaLocation W25529310491 @default.
- W2552931049 hasConcept C109650736 @default.
- W2552931049 hasConcept C17857428 @default.
- W2552931049 hasConcept C181199279 @default.
- W2552931049 hasConcept C185592680 @default.
- W2552931049 hasConcept C2777482532 @default.