FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2552939376> ?p ?o ?g. }

• W2552939376 endingPage "593" @default.
• W2552939376 startingPage "582" @default.
• W2552939376 abstract "In auditory pathways, the precision of action potential (AP) propagation depends on axon myelination and high densities of voltage-gated Na (Na v ) channels clustered at nodes of Ranvier. Changes in Na v channel expression at the heminode, the final node before the nerve terminal, can alter AP invasion into the presynaptic terminal. We studied the activity-dependent formation of Na v channel clusters before and after hearing onset at postnatal day 12 in the rat and mouse auditory brain stem. In rats, the Na v channel cluster at the heminode formed progressively during the second postnatal week, around hearing onset, whereas the Na v channel cluster at the nodes was present before hearing onset. Initiation of heminodal Na v channel clustering was correlated with the expression of scaffolding protein ankyrinG and paranodal protein Caspr. However, in whirler mice with congenital deafness, heminodal Na v channels did not form clusters and maintained broad expression, but Na v channel clustering was normal at the nodes. In addition, a clear difference in the distance from the heminodal Na v channel to the calyx across the mediolateral axis of the medial nucleus of the trapezoid body (MNTB) developed after hearing onset. In the medial MNTB, where neurons respond best to high-frequency sounds, the heminodal Na v channel cluster was located closer to the terminal than in the lateral MNTB, where neurons respond best to low-frequency sounds. Thus sound-mediated neuronal activities are potentially associated with the refinement of the heminode adjacent to the presynaptic terminal in the auditory brain stem. NEW & NOTEWORTHY Clustering of voltage-gated sodium (Na v ) channels and their distribution along the axon, specifically at the unmyelinated axon segment next to the nerve terminal, are essential for tuning propagated action potentials. Na v channel clusters near the nerve terminal and their location as a function of neuronal position along the mediolateral axis are controlled by auditory inputs after hearing onset. Thus sound-mediated neuronal activity influences the tonotopic organization of Na v channels at the nerve terminal in the auditory brain stem." @default.
• W2552939376 created "2016-11-30" @default.
• W2552939376 creator A5000523151 @default.
• W2552939376 creator A5009660402 @default.
• W2552939376 creator A5049258884 @default.
• W2552939376 date "2017-02-01" @default.
• W2552939376 modified "2023-09-28" @default.
• W2552939376 title "Activity-dependent formation and location of voltage-gated sodium channel clusters at a CNS nerve terminal during postnatal development" @default.
• W2552939376 cites W1572933126 @default.
• W2552939376 cites W1580538626 @default.
• W2552939376 cites W1580819952 @default.
• W2552939376 cites W1788586683 @default.
• W2552939376 cites W1877594537 @default.
• W2552939376 cites W1906027843 @default.
• W2552939376 cites W1969797865 @default.
• W2552939376 cites W1977848380 @default.
• W2552939376 cites W1978923377 @default.
• W2552939376 cites W1982110038 @default.
• W2552939376 cites W1984204690 @default.
• W2552939376 cites W1989092549 @default.
• W2552939376 cites W2007663594 @default.
• W2552939376 cites W2022648044 @default.
• W2552939376 cites W2030013301 @default.
• W2552939376 cites W2044364924 @default.
• W2552939376 cites W2044873408 @default.
• W2552939376 cites W2056897764 @default.
• W2552939376 cites W2071271986 @default.
• W2552939376 cites W2087805550 @default.
• W2552939376 cites W2088658062 @default.
• W2552939376 cites W2092166405 @default.
• W2552939376 cites W2116241815 @default.
• W2552939376 cites W2138910749 @default.
• W2552939376 cites W2141036744 @default.
• W2552939376 cites W2152000284 @default.
• W2552939376 cites W2156541195 @default.
• W2552939376 cites W2160497177 @default.
• W2552939376 cites W2164425582 @default.
• W2552939376 cites W2255839289 @default.
• W2552939376 cites W2283764095 @default.
• W2552939376 cites W2350072286 @default.
• W2552939376 cites W2491146427 @default.
• W2552939376 doi "https://doi.org/10.1152/jn.00617.2016" @default.
• W2552939376 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5288486" @default.
• W2552939376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27832602" @default.
• W2552939376 hasPublicationYear "2017" @default.
• W2552939376 type Work @default.
• W2552939376 sameAs 2552939376 @default.
• W2552939376 citedByCount "13" @default.
• W2552939376 countsByYear W25529393762017 @default.
• W2552939376 countsByYear W25529393762018 @default.
• W2552939376 countsByYear W25529393762019 @default.
• W2552939376 countsByYear W25529393762020 @default.
• W2552939376 countsByYear W25529393762021 @default.
• W2552939376 countsByYear W25529393762022 @default.
• W2552939376 crossrefType "journal-article" @default.
• W2552939376 hasAuthorship W2552939376A5000523151 @default.
• W2552939376 hasAuthorship W2552939376A5009660402 @default.
• W2552939376 hasAuthorship W2552939376A5049258884 @default.
• W2552939376 hasBestOaLocation W25529393762 @default.
• W2552939376 hasConcept C12554922 @default.
• W2552939376 hasConcept C169760540 @default.
• W2552939376 hasConcept C178790620 @default.
• W2552939376 hasConcept C185592680 @default.
• W2552939376 hasConcept C2776178378 @default.
• W2552939376 hasConcept C2777037019 @default.
• W2552939376 hasConcept C2777662796 @default.
• W2552939376 hasConcept C2778609137 @default.
• W2552939376 hasConcept C2779530196 @default.
• W2552939376 hasConcept C2780723820 @default.
• W2552939376 hasConcept C50952357 @default.
• W2552939376 hasConcept C529278444 @default.
• W2552939376 hasConcept C537181965 @default.
• W2552939376 hasConcept C86803240 @default.
• W2552939376 hasConceptScore W2552939376C12554922 @default.
• W2552939376 hasConceptScore W2552939376C169760540 @default.
• W2552939376 hasConceptScore W2552939376C178790620 @default.
• W2552939376 hasConceptScore W2552939376C185592680 @default.
• W2552939376 hasConceptScore W2552939376C2776178378 @default.
• W2552939376 hasConceptScore W2552939376C2777037019 @default.
• W2552939376 hasConceptScore W2552939376C2777662796 @default.
• W2552939376 hasConceptScore W2552939376C2778609137 @default.
• W2552939376 hasConceptScore W2552939376C2779530196 @default.
• W2552939376 hasConceptScore W2552939376C2780723820 @default.
• W2552939376 hasConceptScore W2552939376C50952357 @default.
• W2552939376 hasConceptScore W2552939376C529278444 @default.
• W2552939376 hasConceptScore W2552939376C537181965 @default.
• W2552939376 hasConceptScore W2552939376C86803240 @default.
• W2552939376 hasFunder F4320337352 @default.
• W2552939376 hasIssue "2" @default.
• W2552939376 hasLocation W25529393761 @default.
• W2552939376 hasLocation W25529393762 @default.
• W2552939376 hasLocation W25529393763 @default.
• W2552939376 hasLocation W25529393764 @default.
• W2552939376 hasOpenAccess W2552939376 @default.
• W2552939376 hasPrimaryLocation W25529393761 @default.
• W2552939376 hasRelatedWork W1560962269 @default.
• W2552939376 hasRelatedWork W2001356185 @default.
• W2552939376 hasRelatedWork W2002602712 @default.

• next