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- W2552959969 abstract "Introduction: Size of adrenal glands is affected by gender, obesity, somatic and psychiatric stresses, and an abnormal adrenal endocrine system. Most patients with obstructive sleep apnea (OSA) are obese males who might experience several stresses through OSA-induced intermittent, sustained hypoxemia, arousals, and fragmentation during sleep. Although the size of adrenal glands in OSA patients is expected to be abnormal, this issue has not been investigated. Aims: We hypothesized that the adrenal gland is enlarged in OSA patients, and investigated the association between adrenal size and sleep parameters. Methods: We retrospectively reviewed 133 consecutive patients who underwent polysomnography and abdominal computed tomography (CT) from November 2008 to December 2009. OSA was defined as none/mild (apnea hypopnea index [AHI] Results: The mean of the adrenal limbs was larger in moderate and severe OSA patients than in none/mild OSA patients (3.64, 4.11, and 4.27 mm, respectively, p = 0.005). There was no correlation between plasma catecholamine and adrenal size. Multivariate regression analysis revealed that the arousal index was an independent factor that positively correlated with adrenal size (β = 0.28, p Conclusions: Since not AHI but the arousal index was significantly associated with adrenal size in patients with OSA, elevation in sympathetic nerve activity, which is said to be influenced by arousal and/or fragmentation during sleep, might be associated with adrenal size in patients with OSA." @default.
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- W2552959969 date "2016-09-01" @default.
- W2552959969 modified "2023-09-27" @default.
- W2552959969 title "Adrenal size in patients with obstructive sleep apnea" @default.
- W2552959969 doi "https://doi.org/10.1183/13993003.congress-2016.pa2350" @default.
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