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• W2552966922 abstract "The Wiskott-Aldrich Syndrome Protein and SCAR Homologue (WASH) is a conserved actin nucleation promoting factor controlling Arp2/3 complex activity in endosomal sorting and recycling. Previous studies have identified WASH as an essential regulator in Drosophila development. Here, we show that homozygous wash mutant flies are viable and fertile. We demonstrate that Drosophila WASH has conserved functions in integrin receptor recycling and lysosome neutralization. WASH generates actin patches on endosomes and lysosomes mediating both functions. Consistently, loss of WASH function results in cell spreading and cell migration defects of macrophages, and an increased lysosomal acidification that affects efficient phagocytic and autophagic clearance. WASH physically interacts with the vacuolar ATPase subunit Vha55 that is crucial to establish and maintain lysosome acidification. As a consequence, starved flies lacking WASH function show a dramatic increase in acidic autolysosomes causing a reduced lifespan. Thus, our data highlight a conserved role for WASH in the endocytic sorting and recycling of membrane proteins like integrins and the V-ATPase that increase the likelihood of survival under nutrient deprivation." @default.
• W2552966922 created "2016-11-30" @default.
• W2552966922 creator A5007990179 @default.
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• W2552966922 date "2016-01-01" @default.
• W2552966922 modified "2023-09-26" @default.
• W2552966922 title "<i>Drosophila</i> WASH is required for integrin-mediated cell adhesion, cell motility and lysosomal neutralization" @default.
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• W2552966922 doi "https://doi.org/10.1242/jcs.193086" @default.
• W2552966922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27884932" @default.
• W2552966922 hasPublicationYear "2016" @default.
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