FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2552986243> ?p ?o ?g. }

• W2552986243 endingPage "e0166658" @default.
• W2552986243 startingPage "e0166658" @default.
• W2552986243 abstract "Vascular endothelial growth factor (VEGF) is the most important promotor of angiogenesis. Some studies indicate that anti-angiogenic agents that interfere with VEGF and its receptor (VEGFR), i.e., anti-VEGF/VEGFR agents, may be applied to treat endometriosis. This meta-analysis investigated the efficacy of anti-VEGF/VEGFR agents in animal models of endometriosis.A systematic literature search was performed for animal studies published in English or Chinese from January 1995 to June 2016, which evaluated the effect of anti-VEGF/VEGFR agents on endometriosis. The databases were: PubMed, Web of Science, BIOSIS, Embase, and CNKI. The quality of included studies was assessed using the SYRCLE tool. The random-effect models were used to combine the results of selected studies. Heterogeneity was assessed using H2statistic and I2 statistic. Subgroup analyses were performed to determine the source of heterogeneity in endometriosis scores and follicle numbers.We identified 13 studies that used anti-VEGF/VEGFR agents in various animal models. The meta-analysis showed that anti-VEGF/VEGFR agents were associated with smaller size (standardized mean difference (SMD) -0.96, 95% CI -1.31 to -0.62; P < 0.0001) and weight (SMD -1.70, 95% CI -2.75 to -0.65; P = 0.002) of endometriosis lesions, relative to the untreated controls, as well as a lower incidence rate of endometriosis (risk ratio 0.26, 95% CI 0.07 to 0.93; P = 0.038) and endometriosis score (SMD -1.17, 95% CI -1.65 to -0.69; P < 0.0001); the number of follicles were similar (SMD -0.78, 95% CI -1.65 to 0.09; P = 0.08).Anti-VEGF/VEGFR agents appeared to inhibit the growth of endometriosis, with no effect on ovarian function. Anti-angiogenic therapy may be a novel strategy in treating endometriosis." @default.
• W2552986243 created "2016-11-30" @default.
• W2552986243 creator A5001595924 @default.
• W2552986243 creator A5059048948 @default.
• W2552986243 creator A5063475696 @default.
• W2552986243 creator A5076021322 @default.
• W2552986243 creator A5087210039 @default.
• W2552986243 creator A5088887376 @default.
• W2552986243 creator A5090120974 @default.
• W2552986243 date "2016-11-17" @default.
• W2552986243 modified "2023-10-18" @default.
• W2552986243 title "Efficacy of Anti-VEGF/VEGFR Agents on Animal Models of Endometriosis: A Systematic Review and Meta-Analysis" @default.
• W2552986243 cites W1777702785 @default.
• W2552986243 cites W1919977976 @default.
• W2552986243 cites W1964435302 @default.
• W2552986243 cites W1966846417 @default.
• W2552986243 cites W1971284794 @default.
• W2552986243 cites W2000833257 @default.
• W2552986243 cites W2005542169 @default.
• W2552986243 cites W2017522308 @default.
• W2552986243 cites W2021667437 @default.
• W2552986243 cites W2030933099 @default.
• W2552986243 cites W2033585778 @default.
• W2552986243 cites W2038320938 @default.
• W2552986243 cites W2056802932 @default.
• W2552986243 cites W2056951482 @default.
• W2552986243 cites W2058571677 @default.
• W2552986243 cites W2061305612 @default.
• W2552986243 cites W2062146531 @default.
• W2552986243 cites W2067360409 @default.
• W2552986243 cites W2086233980 @default.
• W2552986243 cites W2101044166 @default.
• W2552986243 cites W2110225766 @default.
• W2552986243 cites W2110567194 @default.
• W2552986243 cites W2111141200 @default.
• W2552986243 cites W2112885721 @default.
• W2552986243 cites W2115056064 @default.
• W2552986243 cites W2121219736 @default.
• W2552986243 cites W2125435699 @default.
• W2552986243 cites W2126930838 @default.
• W2552986243 cites W2131145289 @default.
• W2552986243 cites W2132577372 @default.
• W2552986243 cites W2141794277 @default.
• W2552986243 cites W2144854739 @default.
• W2552986243 cites W2145383112 @default.
• W2552986243 cites W2157823046 @default.
• W2552986243 cites W2169855351 @default.
• W2552986243 cites W2171127905 @default.
• W2552986243 cites W2410194753 @default.
• W2552986243 cites W4211081176 @default.
• W2552986243 cites W864144567 @default.
• W2552986243 doi "https://doi.org/10.1371/journal.pone.0166658" @default.
• W2552986243 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5113963" @default.
• W2552986243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27855197" @default.
• W2552986243 hasPublicationYear "2016" @default.
• W2552986243 type Work @default.
• W2552986243 sameAs 2552986243 @default.
• W2552986243 citedByCount "36" @default.
• W2552986243 countsByYear W25529862432017 @default.
• W2552986243 countsByYear W25529862432018 @default.
• W2552986243 countsByYear W25529862432019 @default.
• W2552986243 countsByYear W25529862432020 @default.
• W2552986243 countsByYear W25529862432021 @default.
• W2552986243 countsByYear W25529862432022 @default.
• W2552986243 countsByYear W25529862432023 @default.
• W2552986243 crossrefType "journal-article" @default.
• W2552986243 hasAuthorship W2552986243A5001595924 @default.
• W2552986243 hasAuthorship W2552986243A5059048948 @default.
• W2552986243 hasAuthorship W2552986243A5063475696 @default.
• W2552986243 hasAuthorship W2552986243A5076021322 @default.
• W2552986243 hasAuthorship W2552986243A5087210039 @default.
• W2552986243 hasAuthorship W2552986243A5088887376 @default.
• W2552986243 hasAuthorship W2552986243A5090120974 @default.
• W2552986243 hasBestOaLocation W25529862431 @default.
• W2552986243 hasConcept C126322002 @default.
• W2552986243 hasConcept C143998085 @default.
• W2552986243 hasConcept C167734588 @default.
• W2552986243 hasConcept C187960798 @default.
• W2552986243 hasConcept C2777025900 @default.
• W2552986243 hasConcept C2779522080 @default.
• W2552986243 hasConcept C2780394083 @default.
• W2552986243 hasConcept C28804328 @default.
• W2552986243 hasConcept C71924100 @default.
• W2552986243 hasConcept C90924648 @default.
• W2552986243 hasConcept C95190672 @default.
• W2552986243 hasConceptScore W2552986243C126322002 @default.
• W2552986243 hasConceptScore W2552986243C143998085 @default.
• W2552986243 hasConceptScore W2552986243C167734588 @default.
• W2552986243 hasConceptScore W2552986243C187960798 @default.
• W2552986243 hasConceptScore W2552986243C2777025900 @default.
• W2552986243 hasConceptScore W2552986243C2779522080 @default.
• W2552986243 hasConceptScore W2552986243C2780394083 @default.
• W2552986243 hasConceptScore W2552986243C28804328 @default.
• W2552986243 hasConceptScore W2552986243C71924100 @default.
• W2552986243 hasConceptScore W2552986243C90924648 @default.
• W2552986243 hasConceptScore W2552986243C95190672 @default.
• W2552986243 hasIssue "11" @default.
• W2552986243 hasLocation W25529862431 @default.

• next