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• W2553039496 abstract "In continuance of our search for newer antiproliferative agents we report herein the synthesis and antiproliferative studies of two series ( 5a–j and 10a–c ) of heterocyclic compounds. All the new compounds were characterized by IR, NMR, and mass spectral data. The antiproliferative activity of 10 compounds ( 5a–j ) was carried out on HeLa (cervix cancer cell line) and MDA-MB-435 (melanoma) and LC 50 , TGI, and GI 50 were calculated, while the antiproliferative activity of 3 compounds ( 10a–c ) was carried out against nine different panels of nearly 60 cell lines (NCI-60) according to the National Cancer Institute (NCI US) Protocol at 10 μ M. 1-(7-Hydroxy-4-methyl-2-oxoquinolin-1(2 H )-yl)-3-(4-methoxylphenyl)urea ( 5j ) was found to have antiproliferative activity with GI 50 of 35.1 μ M against HeLa (cervix cancer cell line) and 60.4 μ M against MDA-MB-435 (melanoma), respectively. The compounds 10a , 10b , and 10c showed antiproliferative activity with comparatively higher selectivity towards HOP-92 (Non-Small Cell Lung Cancer) with percent growth inhibitions (GIs) of 34.14, 35.29, and 31.59, respectively." @default.
• W2553039496 created "2016-11-30" @default.
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• W2553039496 date "2016-11-24" @default.
• W2553039496 modified "2023-10-16" @default.
• W2553039496 title "Synthesis and Antiproliferative Activity of Some Quinoline and Oxadiazole Derivatives" @default.
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• W2553039496 doi "https://doi.org/10.1155/2016/9589517" @default.
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