Matches in SemOpenAlex for { <https://semopenalex.org/work/W2553047797> ?p ?o ?g. }
- W2553047797 endingPage "e0165278" @default.
- W2553047797 startingPage "e0165278" @default.
- W2553047797 abstract "Background and Aims Data regarding smoking and alcohol consumption and risk of gastrointestinal bleeding (GIB) are sparse and conflicting. We assessed the risk of major GIB associated with smoking and alcohol consumption in a large, prospective cohort. Methods We prospectively studied 48,000 men in the Health Professional follow-up Study (HPFS) who were aged 40–75 years at baseline in 1986. We identified men with major GIB requiring hospitalization and/or blood transfusion via biennial questionnaires and chart review. Results We documented 305 episodes of major GIB during 26 years of follow-up. Men who consumed >30 g/day of alcohol had a multivariable relative risk (RR) of 1.43 (95% confidence interval (CI), 0.88–2.35; P for trend 0.006) for major GIB when compared with nondrinkers. Alcohol consumption appeared to be primarily related to upper GIB (multivariable RR for >30 g/day vs. nondrinkers was 1.35; 95% CI, 0.66–2.77; P for trend 0.02). Men who consumed ≥ 5 drinks/week vs. < 1 drink/month of liquor had a multivariable RR of 1.72 (95% CI, 1.26–2.35, P for trend <0.001). Wine and beer were not significantly associated with major GIB. The risk of GIB associated with NSAIDs/aspirin use increased with greater alcohol consumption (multivariable RR 1.37; 95% CI, 0.85–2.19 for 1-14g/day of alcohol, RR 1.75; 95% CI, 1.07–2.88 for ≥ 15g/day compared to nondrinkers). Smoking was not significantly associated with GIB. Conclusions Alcohol consumption, but not smoking, was associated with an increased risk of major GIB. Associations were most notable for upper GIB associated with liquor intake. Alcohol appeared to potentiate the risk of NSAID-associated GIB." @default.
- W2553047797 created "2016-11-30" @default.
- W2553047797 creator A5003077102 @default.
- W2553047797 creator A5008606748 @default.
- W2553047797 creator A5009694332 @default.
- W2553047797 creator A5034083482 @default.
- W2553047797 creator A5068835941 @default.
- W2553047797 creator A5076961128 @default.
- W2553047797 date "2016-11-08" @default.
- W2553047797 modified "2023-10-16" @default.
- W2553047797 title "A Prospective Study of Alcohol Consumption and Smoking and the Risk of Major Gastrointestinal Bleeding in Men" @default.
- W2553047797 cites W1491439999 @default.
- W2553047797 cites W1778213929 @default.
- W2553047797 cites W1789208348 @default.
- W2553047797 cites W1895778948 @default.
- W2553047797 cites W1907103218 @default.
- W2553047797 cites W1975018044 @default.
- W2553047797 cites W1985130483 @default.
- W2553047797 cites W1989244685 @default.
- W2553047797 cites W1990542465 @default.
- W2553047797 cites W1994626674 @default.
- W2553047797 cites W1995294317 @default.
- W2553047797 cites W1995307883 @default.
- W2553047797 cites W1996159534 @default.
- W2553047797 cites W1997457478 @default.
- W2553047797 cites W2007164294 @default.
- W2553047797 cites W2007517364 @default.
- W2553047797 cites W2015403569 @default.
- W2553047797 cites W2022795312 @default.
- W2553047797 cites W2023176051 @default.
- W2553047797 cites W2027972598 @default.
- W2553047797 cites W2029169136 @default.
- W2553047797 cites W2032999070 @default.
- W2553047797 cites W2043868637 @default.
- W2553047797 cites W2044267165 @default.
- W2553047797 cites W2045065444 @default.
- W2553047797 cites W2045276152 @default.
- W2553047797 cites W2046248633 @default.
- W2553047797 cites W2052260981 @default.
- W2553047797 cites W2052285453 @default.
- W2553047797 cites W2052700582 @default.
- W2553047797 cites W2054867366 @default.
- W2553047797 cites W2055366026 @default.
- W2553047797 cites W2062112003 @default.
- W2553047797 cites W2067221446 @default.
- W2553047797 cites W2071335057 @default.
- W2553047797 cites W2072150424 @default.
- W2553047797 cites W2072222076 @default.
- W2553047797 cites W2076759080 @default.
- W2553047797 cites W2081805513 @default.
- W2553047797 cites W2087545759 @default.
- W2553047797 cites W2107943234 @default.
- W2553047797 cites W2115974358 @default.
- W2553047797 cites W2120021843 @default.
- W2553047797 cites W2128516271 @default.
- W2553047797 cites W2132227714 @default.
- W2553047797 cites W2166587212 @default.
- W2553047797 cites W2170026073 @default.
- W2553047797 cites W4298848786 @default.
- W2553047797 cites W9257107 @default.
- W2553047797 doi "https://doi.org/10.1371/journal.pone.0165278" @default.
- W2553047797 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5100927" @default.
- W2553047797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27824864" @default.
- W2553047797 hasPublicationYear "2016" @default.
- W2553047797 type Work @default.
- W2553047797 sameAs 2553047797 @default.
- W2553047797 citedByCount "30" @default.
- W2553047797 countsByYear W25530477972018 @default.
- W2553047797 countsByYear W25530477972019 @default.
- W2553047797 countsByYear W25530477972020 @default.
- W2553047797 countsByYear W25530477972021 @default.
- W2553047797 countsByYear W25530477972022 @default.
- W2553047797 countsByYear W25530477972023 @default.
- W2553047797 crossrefType "journal-article" @default.
- W2553047797 hasAuthorship W2553047797A5003077102 @default.
- W2553047797 hasAuthorship W2553047797A5008606748 @default.
- W2553047797 hasAuthorship W2553047797A5009694332 @default.
- W2553047797 hasAuthorship W2553047797A5034083482 @default.
- W2553047797 hasAuthorship W2553047797A5068835941 @default.
- W2553047797 hasAuthorship W2553047797A5076961128 @default.
- W2553047797 hasBestOaLocation W25530477971 @default.
- W2553047797 hasConcept C126322002 @default.
- W2553047797 hasConcept C141071460 @default.
- W2553047797 hasConcept C185592680 @default.
- W2553047797 hasConcept C188816634 @default.
- W2553047797 hasConcept C201903717 @default.
- W2553047797 hasConcept C2777628954 @default.
- W2553047797 hasConcept C2781066024 @default.
- W2553047797 hasConcept C44249647 @default.
- W2553047797 hasConcept C55493867 @default.
- W2553047797 hasConcept C71924100 @default.
- W2553047797 hasConcept C82789193 @default.
- W2553047797 hasConceptScore W2553047797C126322002 @default.
- W2553047797 hasConceptScore W2553047797C141071460 @default.
- W2553047797 hasConceptScore W2553047797C185592680 @default.
- W2553047797 hasConceptScore W2553047797C188816634 @default.
- W2553047797 hasConceptScore W2553047797C201903717 @default.
- W2553047797 hasConceptScore W2553047797C2777628954 @default.