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- W2553086543 abstract "Over a century of efforts to categorize the astonishing diversity of cortical neurons has relied on criteria of morphology, electrophysiology, ontology, and the expression of a few transcripts and proteins. The rapid development of single-cell RNA sequencing (scRNA-seq) adds genome-wide gene expression patterns to this list of criteria, and promises to reveal new insights into the transitions that establish neuronal identity during development, differentiation, activity, and disease. Comparing single neuron data to reference atlases constructed from hundreds of thousands of single-cell transcriptomes will be critical to understanding these transitions and the molecular mechanisms that drive them. We review early efforts, and discuss future challenges and opportunities, in applying scRNA-seq to the elucidation of neuronal subtypes and their development." @default.
- W2553086543 created "2016-11-30" @default.
- W2553086543 creator A5003756148 @default.
- W2553086543 creator A5009957197 @default.
- W2553086543 date "2017-02-01" @default.
- W2553086543 modified "2023-09-25" @default.
- W2553086543 title "Cerebral cortical neuron diversity and development at single-cell resolution" @default.
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- W2553086543 doi "https://doi.org/10.1016/j.conb.2016.11.001" @default.
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