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- W2553089324 abstract "Introduction and aim: Different dosages and administration routes of antimicrobials can lead to variability in exposure to the drug. This may affect not only therapeutic efficacy but also resistance selection of the pathogen as well as commensal microbiota, e.g. in the gastro-intestinal tract (GIT). Hence, the aim of the present study was to evaluate intestinal and plasma concentrations of sulfadiazine-trimethoprim (SDZ-TRIM) combinations after oral (PO) as well as intramuscular (IM) administration in pigs, using both conventional dosing according to the leaflet and dose alterations. These data will give valuable insight into the exposure of intestinal microbiota to these antimicrobials.Materials and methods: Thirty-six piglets were divided in six treatment groups. SDZ-TRIM was given orally twice daily during 5 days in group 1 and 2 (gastric intubation) and group 5 and 6 (medicated feed). Dose alterations (half dose) were applied in group 2 and 6. Group 3 and 4 received a daily IM administration during 5 days. Dose alterations were achieved in group 4 (double dose). Blood and manure were collected at different time points during treatment period. Following, the animals were euthanized and content of different intestinal segments (duodenum, jejunum, ileum, cecum, colon and rectum) was collected.Results: Remarkably, high levels of SDZ were detected in the GIT after PO as well as IM administration, and were accumulating towards distal segments. This suggests intestinal secretion of SDZ as this antimicrobial has a high oral bioavailability in pigs and is reported to be mainly renally excreted. In contrast, TRIM concentrations in intestinal content were low, decreasing towards distal parts. Also TRIM has a high oral bioavailability in pigs and is reported to be mainly renally excreted. This implies that no intestinal secretion occurs for TRIM or that it is reabsorbed in the gut following secretion. In conclusion, the intestinal microbiota is exposed to similar concentrations of SDZ-TRIM after PO as well as IM administration. Furthermore, distinct differences in intestinal concentrations are present between SDZ and TRIM." @default.
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- W2553089324 date "2016-01-01" @default.
- W2553089324 modified "2023-09-27" @default.
- W2553089324 title "Plasma and intestinal concentrations of sulfadiazine-trimethoprim in pigs after (non)conventional oral and intramuscular treatment, in the context of antimicrobial resistance" @default.
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