FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2553100788> ?p ?o ?g. }

• W2553100788 endingPage "e0166628" @default.
• W2553100788 startingPage "e0166628" @default.
• W2553100788 abstract "Serum hepcidin concentration is regulated by iron status, inflammation, erythropoiesis and numerous other factors, but underlying processes are incompletely understood. We studied the association of common and rare single nucleotide variants (SNVs) with serum hepcidin in one Italian study and two large Dutch population-based studies. We genotyped common SNVs with genome-wide association study (GWAS) arrays and subsequently performed imputation using the 1000 Genomes reference panel. Cohort-specific GWAS were performed for log-transformed serum hepcidin, adjusted for age and gender, and results were combined in a fixed-effects meta-analysis (total N 6,096). Six top SNVs (p<5x10-6) were genotyped in 3,821 additional samples, but associations were not replicated. Furthermore, we meta-analyzed cohort-specific exome array association results of rare SNVs with serum hepcidin that were available for two of the three cohorts (total N 3,226), but no exome-wide significant signal (p<1.4x10-6) was identified. Gene-based meta-analyses revealed 19 genes that showed significant association with hepcidin. Our results suggest the absence of common SNVs and rare exonic SNVs explaining a large proportion of phenotypic variation in serum hepcidin. We recommend extension of our study once additional substantial cohorts with hepcidin measurements, GWAS and/or exome array data become available in order to increase power to identify variants that explain a smaller proportion of hepcidin variation. In addition, we encourage follow-up of the potentially interesting genes that resulted from the gene-based analysis of low-frequency and rare variants." @default.
• W2553100788 created "2016-11-30" @default.
• W2553100788 creator A5006065540 @default.
• W2553100788 creator A5013598634 @default.
• W2553100788 creator A5018732365 @default.
• W2553100788 creator A5023996952 @default.
• W2553100788 creator A5028492277 @default.
• W2553100788 creator A5045763456 @default.
• W2553100788 creator A5048435323 @default.
• W2553100788 creator A5052368642 @default.
• W2553100788 creator A5053476573 @default.
• W2553100788 creator A5057071664 @default.
• W2553100788 creator A5064212109 @default.
• W2553100788 creator A5068183096 @default.
• W2553100788 creator A5073191678 @default.
• W2553100788 creator A5081175357 @default.
• W2553100788 creator A5084191249 @default.
• W2553100788 creator A5086860007 @default.
• W2553100788 date "2016-11-15" @default.
• W2553100788 modified "2023-10-14" @default.
• W2553100788 title "Meta-GWAS and Meta-Analysis of Exome Array Studies Do Not Reveal Genetic Determinants of Serum Hepcidin" @default.
• W2553100788 cites W1785761853 @default.
• W2553100788 cites W1979307757 @default.
• W2553100788 cites W1980042430 @default.
• W2553100788 cites W1980168725 @default.
• W2553100788 cites W1984636340 @default.
• W2553100788 cites W1990430353 @default.
• W2553100788 cites W1996570221 @default.
• W2553100788 cites W1999149952 @default.
• W2553100788 cites W2000542026 @default.
• W2553100788 cites W2003283154 @default.
• W2553100788 cites W2004451551 @default.
• W2553100788 cites W2011115926 @default.
• W2553100788 cites W2017421607 @default.
• W2553100788 cites W2027624389 @default.
• W2553100788 cites W2031557560 @default.
• W2553100788 cites W2032988531 @default.
• W2553100788 cites W2045008815 @default.
• W2553100788 cites W2048448975 @default.
• W2553100788 cites W2054687040 @default.
• W2553100788 cites W2068815039 @default.
• W2553100788 cites W2076011171 @default.
• W2553100788 cites W2082855795 @default.
• W2553100788 cites W2086702905 @default.
• W2553100788 cites W2087744489 @default.
• W2553100788 cites W2088974549 @default.
• W2553100788 cites W2098510019 @default.
• W2553100788 cites W2107704801 @default.
• W2553100788 cites W2113642938 @default.
• W2553100788 cites W2119165739 @default.
• W2553100788 cites W2123831918 @default.
• W2553100788 cites W2125972459 @default.
• W2553100788 cites W2126989415 @default.
• W2553100788 cites W2133520037 @default.
• W2553100788 cites W2137702285 @default.
• W2553100788 cites W2138195607 @default.
• W2553100788 cites W2138455853 @default.
• W2553100788 cites W2141508574 @default.
• W2553100788 cites W2144753011 @default.
• W2553100788 cites W2144980336 @default.
• W2553100788 cites W2148362837 @default.
• W2553100788 cites W2151950872 @default.
• W2553100788 cites W2152252165 @default.
• W2553100788 cites W2153533315 @default.
• W2553100788 cites W2155679596 @default.
• W2553100788 cites W2170375210 @default.
• W2553100788 cites W2170739303 @default.
• W2553100788 cites W2170885365 @default.
• W2553100788 cites W2343895948 @default.
• W2553100788 cites W3028448231 @default.
• W2553100788 doi "https://doi.org/10.1371/journal.pone.0166628" @default.
• W2553100788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5112847" @default.
• W2553100788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27846281" @default.
• W2553100788 hasPublicationYear "2016" @default.
• W2553100788 type Work @default.
• W2553100788 sameAs 2553100788 @default.
• W2553100788 citedByCount "2" @default.
• W2553100788 countsByYear W25531007882022 @default.
• W2553100788 crossrefType "journal-article" @default.
• W2553100788 hasAuthorship W2553100788A5006065540 @default.
• W2553100788 hasAuthorship W2553100788A5013598634 @default.
• W2553100788 hasAuthorship W2553100788A5018732365 @default.
• W2553100788 hasAuthorship W2553100788A5023996952 @default.
• W2553100788 hasAuthorship W2553100788A5028492277 @default.
• W2553100788 hasAuthorship W2553100788A5045763456 @default.
• W2553100788 hasAuthorship W2553100788A5048435323 @default.
• W2553100788 hasAuthorship W2553100788A5052368642 @default.
• W2553100788 hasAuthorship W2553100788A5053476573 @default.
• W2553100788 hasAuthorship W2553100788A5057071664 @default.
• W2553100788 hasAuthorship W2553100788A5064212109 @default.
• W2553100788 hasAuthorship W2553100788A5068183096 @default.
• W2553100788 hasAuthorship W2553100788A5073191678 @default.
• W2553100788 hasAuthorship W2553100788A5081175357 @default.
• W2553100788 hasAuthorship W2553100788A5084191249 @default.
• W2553100788 hasAuthorship W2553100788A5086860007 @default.
• W2553100788 hasBestOaLocation W25531007881 @default.
• W2553100788 hasConcept C104317684 @default.
• W2553100788 hasConcept C10590036 @default.

• next