FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2553205174> ?p ?o ?g. }

• W2553205174 abstract "Bodempudi V, Hergert P, Smith K, Xia H, Herrera J, Peterson M, Khalil W, Kahm J, Bitterman PB, Henke CA. miR-210 promotes IPF fibroblast proliferation in response to hypoxia. Am J Physiol Lung Cell Mol Physiol 307: L283–L294, 2014. First published June 20, 2014; doi:10.1152/ajplung.00069.2014.—Idiopathic pulmonary fibrosis (IPF) is characterized by the relentless spread of fibroblasts from scarred alveoli into adjacent alveolar units, resulting in progressive hypoxia and death by asphyxiation. Although hypoxia is a prominent clinical feature of IPF, the role of hypoxia as a driver of the progressive fibrotic nature of the disease has not been explored. Here, we demonstrate that hypoxia robustly stimulates the proliferation of IPF fibroblasts. We found that miR-210 expression markedly increases in IPF fibroblasts in response to hypoxia and that knockdown of miR-210 decreases hypoxia-induced IPF fibroblast proliferation. Silencing hypoxia-inducible factor (HIF)-2 inhibits the hypoxia-mediated increase in miR-210 expression and blocks IPF fibroblast proliferation, indicating that HIF-2 is upstream of miR-210. We demonstrate that the miR-210 downstream target MNT is repressed in hypoxic IPF fibroblasts and that knockdown of miR-210 increases MNT expression. Overexpression of MNT inhibits hypoxiainduced IPF fibroblast proliferation. Together, these data indicate that hypoxia potently stimulates miR-210 expression via HIF-2 , and high miR-210 expression drives fibroblast proliferation by repressing the c-myc inhibitor, MNT. In situ analysis of IPF lung tissue demonstrates miR-210 expression in a similar distribution with HIF-2 and the hypoxic marker carbonic anhydrase-IX in cells within the IPF fibrotic reticulum. Our results raise the possibility that a pathological feedforward loop exists in the IPF lung, in which hypoxia promotes IPF fibroblast proliferation via stimulation of miR-210 expression, which in turn worsens hypoxia." @default.
• W2553205174 created "2016-11-30" @default.
• W2553205174 creator A5018175917 @default.
• W2553205174 creator A5034294832 @default.
• W2553205174 creator A5044041896 @default.
• W2553205174 creator A5045622715 @default.
• W2553205174 creator A5045718681 @default.
• W2553205174 creator A5062721299 @default.
• W2553205174 creator A5064776202 @default.
• W2553205174 creator A5079844729 @default.
• W2553205174 creator A5088897085 @default.
• W2553205174 creator A5090141377 @default.
• W2553205174 date "2014-01-01" @default.
• W2553205174 modified "2023-09-27" @default.
• W2553205174 title "CALL FOR PAPERS: Translational Research in Acute Lung Injury and Pulmonary Fibrosis miR-210 promotes IPF fibroblast proliferation in response to hypoxia" @default.
• W2553205174 cites W1493048246 @default.
• W2553205174 cites W1506462561 @default.
• W2553205174 cites W1510871961 @default.
• W2553205174 cites W154856494 @default.
• W2553205174 cites W1605189746 @default.
• W2553205174 cites W195525803 @default.
• W2553205174 cites W1967063990 @default.
• W2553205174 cites W1969994476 @default.
• W2553205174 cites W1988357840 @default.
• W2553205174 cites W1993489616 @default.
• W2553205174 cites W1996532833 @default.
• W2553205174 cites W2002132361 @default.
• W2553205174 cites W2003670869 @default.
• W2553205174 cites W2005791384 @default.
• W2553205174 cites W2009466546 @default.
• W2553205174 cites W2011925011 @default.
• W2553205174 cites W2018809578 @default.
• W2553205174 cites W2031074041 @default.
• W2553205174 cites W2039075677 @default.
• W2553205174 cites W2039546066 @default.
• W2553205174 cites W2041748697 @default.
• W2553205174 cites W2043757585 @default.
• W2553205174 cites W2053470746 @default.
• W2553205174 cites W2054791783 @default.
• W2553205174 cites W2065988977 @default.
• W2553205174 cites W2074629894 @default.
• W2553205174 cites W2076437605 @default.
• W2553205174 cites W2076451076 @default.
• W2553205174 cites W2076511129 @default.
• W2553205174 cites W2086791508 @default.
• W2553205174 cites W2099416436 @default.
• W2553205174 cites W2102039151 @default.
• W2553205174 cites W2102882750 @default.
• W2553205174 cites W2107458437 @default.
• W2553205174 cites W2113068746 @default.
• W2553205174 cites W2116000536 @default.
• W2553205174 cites W2121164913 @default.
• W2553205174 cites W2121238553 @default.
• W2553205174 cites W2127749277 @default.
• W2553205174 cites W2134215992 @default.
• W2553205174 cites W2135687519 @default.
• W2553205174 cites W2138312235 @default.
• W2553205174 cites W2139128338 @default.
• W2553205174 cites W2140735560 @default.
• W2553205174 cites W2140881215 @default.
• W2553205174 cites W2144009262 @default.
• W2553205174 cites W2145323170 @default.
• W2553205174 cites W2156730414 @default.
• W2553205174 cites W2160889581 @default.
• W2553205174 cites W2320312955 @default.
• W2553205174 hasPublicationYear "2014" @default.
• W2553205174 type Work @default.
• W2553205174 sameAs 2553205174 @default.
• W2553205174 citedByCount "0" @default.
• W2553205174 crossrefType "journal-article" @default.
• W2553205174 hasAuthorship W2553205174A5018175917 @default.
• W2553205174 hasAuthorship W2553205174A5034294832 @default.
• W2553205174 hasAuthorship W2553205174A5044041896 @default.
• W2553205174 hasAuthorship W2553205174A5045622715 @default.
• W2553205174 hasAuthorship W2553205174A5045718681 @default.
• W2553205174 hasAuthorship W2553205174A5062721299 @default.
• W2553205174 hasAuthorship W2553205174A5064776202 @default.
• W2553205174 hasAuthorship W2553205174A5079844729 @default.
• W2553205174 hasAuthorship W2553205174A5088897085 @default.
• W2553205174 hasAuthorship W2553205174A5090141377 @default.
• W2553205174 hasConcept C104317684 @default.
• W2553205174 hasConcept C119056186 @default.
• W2553205174 hasConcept C126322002 @default.
• W2553205174 hasConcept C142724271 @default.
• W2553205174 hasConcept C173396325 @default.
• W2553205174 hasConcept C178790620 @default.
• W2553205174 hasConcept C185592680 @default.
• W2553205174 hasConcept C2777714996 @default.
• W2553205174 hasConcept C2778341716 @default.
• W2553205174 hasConcept C2780381497 @default.
• W2553205174 hasConcept C2780559512 @default.
• W2553205174 hasConcept C2781244666 @default.
• W2553205174 hasConcept C502942594 @default.
• W2553205174 hasConcept C540031477 @default.
• W2553205174 hasConcept C54355233 @default.
• W2553205174 hasConcept C55493867 @default.
• W2553205174 hasConcept C62112901 @default.
• W2553205174 hasConcept C71924100 @default.
• W2553205174 hasConcept C7836513 @default.
• W2553205174 hasConcept C81885089 @default.

• next