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• W2553224965 abstract "Anthracyclines, trastuzumab, and radiotherapy are constitutive components of modern breast-cancer management. The use of these agents has led to significant advances in patient outcome. However, their cardiotoxic adverse effects have been acknowledged since the introduction of these treatments. Potential risk factors responsible for development of anticancer treatment-induced cardiac dysfunction and congestive heart failure are nowadays the topic of active research. Patient-related risk factors include classical cardiovascular risk factors such as age, gender, preexisting cardiovascular disease, and mechanisms that subtend innate sensitivity of patients to anthracycline-induced cardiotoxicity, such as genetic predisposition. Treatment-related risk factors are cumulative dose, administration rate, and synergic adverse effects due to combined therapy. It is imperative to widen the knowledge and assess the cumulative and/or relative risk of possible risk factors that may predispose to treatment-induced cardiotoxicity in order to modulate patient-tailored therapy." @default.
• W2553224965 created "2016-11-30" @default.
• W2553224965 creator A5043760436 @default.
• W2553224965 date "2017-01-01" @default.
• W2553224965 modified "2023-09-24" @default.
• W2553224965 title "Genetic and Epigenetic Risk Factors" @default.
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• W2553224965 doi "https://doi.org/10.1016/b978-0-12-802509-3.00007-8" @default.
• W2553224965 hasPublicationYear "2017" @default.
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