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• W2553239728 endingPage "11468" @default.
• W2553239728 startingPage "11459" @default.
• W2553239728 abstract "Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain neurons in the CNS during development and control plasticity in the adult CNS. They appear to contribute to a wide range of diseases/disorders of the brain, are involved in recovery from spinal cord injury, and are altered during aging, learning and memory, and after exposure to drugs of abuse. Here the focus is on how a major component of PNNs, chondroitin sulfate proteoglycans, control plasticity, and on the role of PNNs in memory in normal aging, in a tauopathy model of Alzheimer's disease, and in drug addiction. Also discussed is how altered extracellular matrix/PNN formation during development may produce synaptic pathology associated with schizophrenia, bipolar disorder, major depression, and autism spectrum disorders. Understanding the molecular underpinnings of how PNNs are altered in normal physiology and disease will offer insights into new treatment approaches for these diseases." @default.
• W2553239728 created "2016-11-30" @default.
• W2553239728 creator A5017383692 @default.
• W2553239728 creator A5022429042 @default.
• W2553239728 creator A5022556246 @default.
• W2553239728 creator A5029239892 @default.
• W2553239728 creator A5038362373 @default.
• W2553239728 creator A5063956093 @default.
• W2553239728 creator A5085808382 @default.
• W2553239728 date "2016-11-09" @default.
• W2553239728 modified "2023-10-14" @default.
• W2553239728 title "Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity" @default.
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