FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2553247612> ?p ?o ?g. }

• W2553247612 endingPage "218" @default.
• W2553247612 startingPage "209" @default.
• W2553247612 abstract "Oleuropein is the pungent principle of raw olives. Oleuropein aglycone (OA) is a major phenolic compound in extra virgin olive oil and the absorbed form of oleuropein. We aimed to determine the mechanism underlying the nutritional effects of oleuropein and OA on interscapular brown adipose tissue (IBAT) in rats with high-fat (HF) diet-induced obesity by examining the agonistic activity of oleuropein and OA toward the transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1). Four-week-old male Sprague-Dawley rats were fed an HF (palm oil 30% wt:wt) diet alone or with oleuropein (HF-O, 1 g/kg diet) for 28 days. In rats fed HF-O compared to HF, urinary noradrenaline, adrenaline and UCP1 levels in IBAT were significantly higher, whereas plasma leptin levels and the total weight of the abdominal cavity adipose tissue were significantly lower. In anaesthetized 7-week-old male Sprague-Dawley rats, the OA (3.8 mg of intravenous injection)-induced increase in plasma noradrenaline secretion was suppressed by TRPA1 or TRPV1 antagonist and by a β2- or β3-adrenoceptor antagonist. Furthermore, OA-activated rat and human TRPV1s expressed on HEK293 cells at the same level as zingerone (pungent component in ginger). OA also activated humanTRPA1, and its potency was approximately 10-fold stronger than that for TRPV1. These findings suggest that OA is the agonist of both TRPA1 and TRPV1 and that OA enhances UCP1 expression in IBAT with a concomitant decrease in the visceral fat mass of HF-diet-induced obese rats through enhanced noradrenaline secretion via β-adrenergic action following TRPA1 and TRPV1 activation." @default.
• W2553247612 created "2016-11-30" @default.
• W2553247612 creator A5002960598 @default.
• W2553247612 creator A5007426726 @default.
• W2553247612 creator A5012245020 @default.
• W2553247612 creator A5022154058 @default.
• W2553247612 creator A5046820883 @default.
• W2553247612 creator A5047664416 @default.
• W2553247612 creator A5068445895 @default.
• W2553247612 creator A5078675709 @default.
• W2553247612 date "2017-02-01" @default.
• W2553247612 modified "2023-10-18" @default.
• W2553247612 title "Oleuropein aglycone enhances UCP1 expression in brown adipose tissue in high-fat-diet-induced obese rats by activating β-adrenergic signaling" @default.
• W2553247612 cites W1512703572 @default.
• W2553247612 cites W166981585 @default.
• W2553247612 cites W1719691205 @default.
• W2553247612 cites W183454965 @default.
• W2553247612 cites W1865891749 @default.
• W2553247612 cites W1919332461 @default.
• W2553247612 cites W1931079797 @default.
• W2553247612 cites W1965079305 @default.
• W2553247612 cites W1968394162 @default.
• W2553247612 cites W1972836378 @default.
• W2553247612 cites W1976825731 @default.
• W2553247612 cites W1979189704 @default.
• W2553247612 cites W1979276465 @default.
• W2553247612 cites W1982043650 @default.
• W2553247612 cites W1983469840 @default.
• W2553247612 cites W1984497619 @default.
• W2553247612 cites W1999400921 @default.
• W2553247612 cites W2005827500 @default.
• W2553247612 cites W2008285801 @default.
• W2553247612 cites W2009789674 @default.
• W2553247612 cites W2010165261 @default.
• W2553247612 cites W2010600097 @default.
• W2553247612 cites W2015439658 @default.
• W2553247612 cites W2017802456 @default.
• W2553247612 cites W2021620130 @default.
• W2553247612 cites W2026701024 @default.
• W2553247612 cites W2027753197 @default.
• W2553247612 cites W2028033722 @default.
• W2553247612 cites W2032484284 @default.
• W2553247612 cites W2040328785 @default.
• W2553247612 cites W2056109880 @default.
• W2553247612 cites W2058145440 @default.
• W2553247612 cites W2059455934 @default.
• W2553247612 cites W2077145490 @default.
• W2553247612 cites W2080098347 @default.
• W2553247612 cites W2081120555 @default.
• W2553247612 cites W2090483434 @default.
• W2553247612 cites W2101575023 @default.
• W2553247612 cites W2102159876 @default.
• W2553247612 cites W2103504291 @default.
• W2553247612 cites W2111517662 @default.
• W2553247612 cites W2125300901 @default.
• W2553247612 cites W2132358997 @default.
• W2553247612 cites W2135810057 @default.
• W2553247612 cites W2141508633 @default.
• W2553247612 cites W2146998282 @default.
• W2553247612 cites W2148403435 @default.
• W2553247612 cites W2156760346 @default.
• W2553247612 cites W2157648968 @default.
• W2553247612 cites W2168526937 @default.
• W2553247612 cites W2172245458 @default.
• W2553247612 cites W2291622011 @default.
• W2553247612 cites W2323521679 @default.
• W2553247612 cites W2510389113 @default.
• W2553247612 cites W4231420687 @default.
• W2553247612 doi "https://doi.org/10.1016/j.jnutbio.2016.11.009" @default.
• W2553247612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27951473" @default.
• W2553247612 hasPublicationYear "2017" @default.
• W2553247612 type Work @default.
• W2553247612 sameAs 2553247612 @default.
• W2553247612 citedByCount "39" @default.
• W2553247612 countsByYear W25532476122017 @default.
• W2553247612 countsByYear W25532476122018 @default.
• W2553247612 countsByYear W25532476122019 @default.
• W2553247612 countsByYear W25532476122020 @default.
• W2553247612 countsByYear W25532476122021 @default.
• W2553247612 countsByYear W25532476122022 @default.
• W2553247612 countsByYear W25532476122023 @default.
• W2553247612 crossrefType "journal-article" @default.
• W2553247612 hasAuthorship W2553247612A5002960598 @default.
• W2553247612 hasAuthorship W2553247612A5007426726 @default.
• W2553247612 hasAuthorship W2553247612A5012245020 @default.
• W2553247612 hasAuthorship W2553247612A5022154058 @default.
• W2553247612 hasAuthorship W2553247612A5046820883 @default.
• W2553247612 hasAuthorship W2553247612A5047664416 @default.
• W2553247612 hasAuthorship W2553247612A5068445895 @default.
• W2553247612 hasAuthorship W2553247612A5078675709 @default.
• W2553247612 hasConcept C126322002 @default.
• W2553247612 hasConcept C134018914 @default.
• W2553247612 hasConcept C142724271 @default.
• W2553247612 hasConcept C155164980 @default.
• W2553247612 hasConcept C160145004 @default.
• W2553247612 hasConcept C170493617 @default.
• W2553247612 hasConcept C171089720 @default.
• W2553247612 hasConcept C185592680 @default.

• next